利索-全球专利检索

  1. 登录
  2. 注册
发明授权
US5550162A N-(-3-aminopropyl)-N-phenyl-5,6,7,8-tetrahydro-naphthalene-2-carboxamide derivatives, their preparation and their therapeutic use 失效
N-（3-氨基丙基）-N-苯基-5,6,7,8-四氢 - 萘-2-甲酰胺衍生物，其制备及其治疗用途

N-(-3-aminopropyl)-N-phenyl-5,6,7,8-tetrahydro-naphthalene-2-carboxamide derivatives, their preparation and their therapeutic use
摘要：
Compounds of the formula: ##STR1## in which R.sub.1 represents a hydrogen or halogen atom or a methyl or C.sub.1 -C.sub.4 alkoxy group, R'.sub.1 represents a hydrogen or halogen atom, R".sub.1 represents a hydrogen atom or a methoxy group, R.sub.3 represents a C.sub.1 -C.sub.3 alkyl group, R.sub.4 represents a 2,3-dihydro-1H-inden-2-yl, 2,3-dihydro-1H-inden-1-yl or 1,2,3,4-tetrahydronaphthalen-1-yl group, or R.sub.3 and R.sub.4 together form, with the adjacent nitrogen atom, a 1,2,3,4-tetrahydroisoquinol-2-yl, 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinol-2-yl, 5,8-dimethoxy-1,2,3,4-tetrahydroisoquinol-2-yl, 1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indol-2-yl, 1,2,3,4-tetrahydro-9H-pyrido[4,3-b]indol-3-yl, 4,5,6,7-tetrahydrothieno[2,3-c]pyrid-6-yl, 2,3-dihydro-1H-isoindol-2-yl or 2,3,4,5-tetra-hydro-1H-3-benzazepin-3-yl, group are useful in the treatment of cerebral disorders.
摘要（中）：

下式的化合物：其中R 1表示氢或卤素原子或甲基或C 1 -C 4烷氧基，R 1表示氢或卤素原子，R“1表示氢原子或 甲氧基，R 3表示C 1 -C 3烷基，R 4表示2,3-二氢-1H-茚-2-基，2,3-二氢-1H-茚-1-基或1,2,3,4 四氢萘-1-基或R3和R4一起与相邻的氮原子一起形成1,2,3,4-四氢异喹啉-2-基，6,7-二甲氧基-1,2,3,4-四氢萘-1-基， 四氢异喹啉-2-基，5,8-二甲氧基-1,2,3,4-四氢异喹啉-2-基，1,2,3,4-四氢-9H-吡啶并[3,4-b] -1,2,3,4-四氢-9H-吡啶并[4,3-b]吲哚-3-基，4,5,6,7-四氢噻吩并[2,3-c]吡啶-6-基， 2,3-二氢-1H-异吲哚-2-基或2,3,4,5-四氢-1H-3-苯并氮杂-3-基可用于治疗脑部疾病。

公开/授权文献
信息查询
Global Dossier
Espacenet
0/0