发明授权
US5550172A Utilization of biocompatible adhesive/sealant materials for securing
surgical devices
失效
利用生物相容的粘合剂/密封剂材料来固定外科手术器械
- 专利标题: Utilization of biocompatible adhesive/sealant materials for securing surgical devices
- 专利标题(中): 利用生物相容的粘合剂/密封剂材料来固定外科手术器械
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申请号: US385015申请日: 1995-02-07
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公开(公告)号: US5550172A公开(公告)日: 1996-08-27
- 发明人: Donald W. Regula , Kevin Cooper , Michael F. Bregen , Shawn T. Huxel , Daniel C. Rosenman
- 申请人: Donald W. Regula , Kevin Cooper , Michael F. Bregen , Shawn T. Huxel , Daniel C. Rosenman
- 申请人地址: NJ Somerville
- 专利权人: Ethicon, Inc.
- 当前专利权人: Ethicon, Inc.
- 当前专利权人地址: NJ Somerville
- 主分类号: A61L24/00
- IPC分类号: A61L24/00 ; A61L24/02 ; A61L24/04 ; A61L24/06 ; A61L27/00 ; C08K5/10 ; A61B17/56 ; A61B17/58 ; C01B15/16
摘要:
A process for enhancing the security of implantable surgical devices secured to bone tissue comprising implanting in bone tissue a surgical device with a biocompatible adhesive and/or sealant selected from the group consisting of: p1 (a) a material made from monomers of the formula:CHR.sup.1 .dbd.CX.sup.1 Y.sup.1 wherein X.sup.1 and Y.sup.1 are each strong electron withdrawing groups, and R.sup.1 is hydrogen or, provided that X.sup.1 and Y.sup.1 are both cyano groups, a C.sub.1 -C.sub.4 alkyl group;(b) a semi-crystalline aliphatic poly(ester) of the formula:[--0--R.sup.11 --C(0)--].sub.y, wherein R.sup.11 is selected from the group consisting of --CR.sup.12 H--, --(CH.sub.2).sub.3 --0--, --CH.sub.2 --CH.sub.2 --O--CH.sub.2 --, CR.sub.12 H--CH.sub.2, --(CH.sub.2).sub.4 --, --(CH.sub.2).sub.z --O--C(O)-- and --(CH.sub.2).sub.z --C(O)--CH.sub.2 --; R.sup.12 is hydrogen or methyl; z is an integer in the range of from 1 to 7 and y is an integer in the range of from about 10 to about 20,000; and(c) a slurry of water and a calcium containing compounds with the general formula:M.sup.2+.sub.10-n N.sup.1+.sub.2n (WO.sub.4.sup.3-).sub.6 mU.sup.2- where n is an integer from 1 to 10, and m is 2 when x is 1, or m is 1 when x is 2, M and N are alkali or alkaline earth metals; WO.sub.4 is an acid radical and w is phosphorus, vanadium, sulfur, silicon, or is substituted in whole or part with carbonate (CO.sub.3.sup.2-); and U is a halide, hydroxide, or carbonate; provided in an amount effective to increase the amount of force necessary to remove the implanted surgical device. Additionally provided is a surgical device that is at least partially coated with at least one biocompatible adhesive and/or sealant.
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