Abstract:
Synthetic polymer substrates comprising a hierarchical surface structure of multiple domes and multiple pillars on said domes, wherein said substrate is a synthetic polymer film, said domes have diameters in the range from about 5 μm to about 400 μm, heights in the range from about 2.5 μm and about 500 μm, and said pillars have diameters in the range from about 20 nm to about 5 μm and aspect ratios of from about 2 to about 50, and methods of making and using them.
Abstract:
A blood clotting substrate and device which has a plurality of oxygen plasma-treated polypropylene pillars extending from the surface of a polypropylene film.
Abstract:
The present invention includes methods for the inhibition of post-operative adhesion formation between tissue surfaces in a body cavity having been subjected to a surgical procedure, which methods involve administering Pemirolast, or an analog thereof, directly to tissue surfaces in the body cavity in amounts and under conditions effective to inhibit formation of adhesions, and to delivery vehicles and compositions suitable for use for local, non-systemic administration of a drug to the body and directly to tissue within a body cavity having been subjected to a surgical procedure.
Abstract:
A device for use in tissue repair procedures, a surgical tissue repair procedure, and a method of making the device. Specifically, the device is an assembly of a cannulated anchor member with a cord passed through it, and a stopper mounted to an end of the cord to prevent the cord from passing back through the anchor member.
Abstract:
A composite having a poly(ethylene-co-acrylic acid) coupling agent, a filler, and a biocompatible, biodegradable polymer matrix is disclosed. The composites described herein are useful for biomedical applications such as, tissue engineering, drug delivery, and implantable medical devices.
Abstract:
A device for use in tissue repair procedures, a surgical tissue repair procedure, and a method of making the device. Specifically, the device is an assembly of a cannulated anchor member with a cord passed through it, and a stopper mounted to an end of the cord to prevent the cord from passing back through the anchor member.
Abstract:
Crosslinked lactam polymers are disclosed. Specifically, lactam polymers having pendant acrylate groups are crosslinked via a Michael addition type acrylate reactant. The crosslinked lactam polymers are useful in medical and pharmaceutical applications.
Abstract:
Various embodiments of thermochromatic compositions and devices and methods of making thermochromatic compositions and devices are provided. One embodiment comprises a thermochromatic composition comprising: a binding material; a thermochromatic material having a first color state a first temperature and a second color state at a second temperature; and a filler material for improving the thermal conductivity of the thermochromatic composition.
Abstract:
A device for use in tissue repair procedures, a surgical tissue repair procedure, and a method of making the device. Specifically, the device is an assembly of a cannulated anchor member with a cord passed through it, and a stopper mounted to an end of the cord to prevent the cord from passing back through the anchor member.
Abstract:
Methods of using inhibitors of the CD2/LFA-3 interaction-in treating skin conditions characterized by increased T cell activation and abnormal antigen presentation in the dermis and epidermis in mammals, including humans. Such conditions include psoriasis, UV damage, e.g., photoaging, atopic dermatitis, cutaneous T cell lymphoma such as mycosis fungoides, allergic and irritant contact dermatitis, lichen planus, alopecia areata, pyoderma gangrenosum, vitiligo, ocular cicatricial pemphigoid, and urticaria.