A child resistant, snap on, twist off closure container package which is open by squeezing and deflecting diametrically opposed side portions of the closure to bring cam followers into engagement which cams on the container so that subsequent turning causes axial displacement and opening movement of the closure from the container. Guide members prevent deforming of the closure to maintain sealing surfaces and adjoining surfaces of the closure and container in alignment with each other and prevent distortion on to expose surfaces which can be gripped by the fingers or teeth in an effort to open the closure and container in a manner other than the intended method of squeezing and twisting of the closure relative to the container.