发明授权
US5556850A Crystalline acid addition salts of diastereomerically pure
1-(2,2-dimethyl-propionyloxy)-ethyl-3-cephem-4-carboxylate
失效
非对映体纯的1-（2,2-二甲基 - 丙酰氧基） - 乙基-3-头孢烯-4-羧酸的结晶酸加成盐
- 专利标题： Crystalline acid addition salts of diastereomerically pure 1-(2,2-dimethyl-propionyloxy)-ethyl-3-cephem-4-carboxylate
- 专利标题（中）： 非对映体纯的1-（2,2-二甲基 - 丙酰氧基） - 乙基-3-头孢烯-4-羧酸的结晶酸加成盐
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申请号： US447635申请日： 1995-05-23
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公开(公告)号： US5556850A公开(公告)日： 1996-09-17
- 发明人: Elisabeth Defossa , Gerd Fischer , Joachim-Heiner Jendralla , Rudolf Lattrell , Theodor Wollmann , Dieter Isert
- 申请人： Elisabeth Defossa , Gerd Fischer , Joachim-Heiner Jendralla , Rudolf Lattrell , Theodor Wollmann , Dieter Isert
- 申请人地址： DEX Frankfurt am Main
- 专利权人： Hoechst Aktiengesellschaft
- 当前专利权人： Hoechst Aktiengesellschaft
- 当前专利权人地址： DEX Frankfurt am Main
- 优先权： DEX4116937.9 19910521
- 主分类号： A61K31/545
- IPC分类号： A61K31/545 ; A61K31/546 ; A61P31/04 ; C07B57/00 ; C07D417/12 ; C07D501/00 ; C07D501/12 ; C07D501/18 ; C07D501/32 ; C07D501/34
摘要：
The invention relates to crystalline acid addition salt of the two diastereomers of the 1-(2,2-dimethylpropionyloxy)ethyl 3-cephem-4-carboxylate of the general formula II ##STR1## in which X is the anion of a physiologically acceptable, mono- or polybasic, inorganic or organic acid and the group .dbd.N--OH is in the syn-position, pharmaceutical formulations which are active against bacterial infections and contain such cephem derivatives, processes for the preparation of the cephem derivatives and the use of the cephem derivatives for combating bacterial infections.
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