发明授权
US5565449A Nonpeptidyl integrin inhibitors having specificity for the GPII.sub.b
III.sub.a receptor
失效
对GPIIbIIIa受体具有特异性的非肽基整联蛋白抑制剂
- 专利标题： Nonpeptidyl integrin inhibitors having specificity for the GPII.sub.b III.sub.a receptor
- 专利标题（中）： 对GPIIbIIIa受体具有特异性的非肽基整联蛋白抑制剂
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申请号： US452479申请日： 1995-05-26
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公开(公告)号： US5565449A公开(公告)日： 1996-10-15
- 发明人: Brent Blackburn , Peter Barker , Thomas Gadek , Robert McDowell , Lawrence McGee , Todd Somers , Rob Webb , Kirk Robarge
- 申请人： Brent Blackburn , Peter Barker , Thomas Gadek , Robert McDowell , Lawrence McGee , Todd Somers , Rob Webb , Kirk Robarge
- 申请人地址： CA South San Francisco
- 专利权人： Genentech, Inc.
- 当前专利权人： Genentech, Inc.
- 当前专利权人地址： CA South San Francisco
- 主分类号： C07D223/16
- IPC分类号： C07D223/16 ; C07D243/10 ; C07D243/14 ; C07D267/14 ; A61K31/55
摘要：
A benzodiazepinedione derivative which acts as a nonpeptidyl platelet aggregation inhibitor is provided. This inhibitor potently inhibits fibrinogen binding to the GPII.sub.b III.sub.a receptor and is provided in therapeutic compositions for the treatment of diseases for which blocking platelet aggregation is indicated. These nonpeptidyl inhibitors are provided in combination with thrombolytics and anticoagulants.
公开/授权文献
- US5008315A Composition 公开/授权日：1991-04-16
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