发明授权
- 专利标题： RNA import elements for transport into mitochondria
- 专利标题（中）： RNA进口元素运输到线粒体
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申请号： US76094申请日： 1993-06-11
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公开(公告)号： US5569754A公开(公告)日： 1996-10-29
- 发明人: R. Sanders Williams , Kang Li
- 申请人： R. Sanders Williams , Kang Li
- 申请人地址： TX Austin
- 专利权人： Board of Regents, University of TX Systems
- 当前专利权人： Board of Regents, University of TX Systems
- 当前专利权人地址： TX Austin
- 主分类号： C12N9/22
- IPC分类号： C12N9/22 ; C12N15/85 ; C07H21/02 ; C07H21/04 ; C12N15/70
摘要：
The invention relates to small RNAs encoded within the nucleus of mammalian cells that specifically import to the mitochondria. The RNAs bind to several nucleolar peptides and thus provide potential carriers for import of biological molecules, including metabolites and proteins, into the mitochondrial compartment. Mitochondrial dysfunction in several maternally inherited human diseases may be correctable employing linkage of mitochondrial import signal to mitochondrial tRNA sequences expressed from nuclear trans-genes without requirement for direct genetic transformation of mitochondria.
公开/授权文献
- USD397620S Watch case 公开/授权日：1998-09-01
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