A self-activated blood drop generator device comprising a casing having an internal hollow and blade assembly disposed within the hollow of the casing for generating an incision in a patient's skin. The device includes a fork-shaped triggering mechanism coupled to the blade assembly for propelling the blade assembly through a predetermined path. A cam arrangement associated with the casing causes the cutting portion of the blade assembly to travel through an arcuate scapel-like path as the cutting portion passes through an aperture in the casing. A retractor arrangement associated with the casing, the blade assembly and the triggering mechanism, are provided for retracting the blade assembly into the hollow of the casing. Also provided is accelerator arrangement associated with the casing and the triggering mechanism for accelerating the triggering mechanism through the hollow of the casing thereby causing the blade assembly to accelerate through the predetermined path. The activation of the device causes the cutting portion of the blade to travel out of the hollow of the casing through the aperture to incise the patient's skin and then retract back through the aperture into the hollow of the casing.