发明授权
- 专利标题： Modified GAF polypeptides
- 专利标题（中）： 改良的GAF多肽
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申请号： US172328申请日： 1993-12-21
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公开(公告)号： US5571895A公开(公告)日： 1996-11-05
- 发明人: Tsutomu Kurokawa , Ken-ichi Kuroshima , Sumie Yoshitomi , Chisako Seko
- 申请人： Tsutomu Kurokawa , Ken-ichi Kuroshima , Sumie Yoshitomi , Chisako Seko
- 申请人地址： JPX Osaka
- 专利权人： Takeda Chemical Industries, Ltd.
- 当前专利权人： Takeda Chemical Industries, Ltd.
- 当前专利权人地址： JPX Osaka
- 优先权： JPX4-342100 19921222; JPX5-207719 19930823
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; A61K39/00 ; C07K14/50 ; C07K16/22 ; C12N15/12 ; C12P21/08 ; C07K14/475
摘要：
The present invention relates to a glia activating factor (GAF) in which 33 to 49 N-terminal amino acids are deleted from the N-terminus of the GAF polypeptide of SEQ ID NO: 3, as well as an anti-GAF antibody which is highly sensitive to assay the GAF and is capable of neutralizing GAF's activity, is produced.Using the antibody, GAF and its biological activity can be assayed easily with high sensitivity. Further, the neutralizing antibody can be expected to have preventive and curative effects on diseases caused by GAF's excessive action. Furthermore, the GAF polypeptide disclosed herein is more stable to acids and heat than the conventional GAFs, therefore, it can be used as a platelet-increasing agent, etc., more advantageously than the previously known GAFs.
公开/授权文献
- US4269988A Biocidal mercaptotriazole haloacrylylnitrile compounds 公开/授权日：1981-05-26
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