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US5574069A Substituted benzenesulfonylureas and -thioureas- process for their preparation and their use as pharmaceuticals 失效
取代苯磺酰脲和硫脲 - 其制备方法及其作为药物的用途

Substituted benzenesulfonylureas and -thioureas- process for their
preparation and their use as pharmaceuticals
摘要:
Benzenesulfonylureas and -thioureas of the formula I ##STR1## where R(1) is H or (fluoro)methyl, R(2) is H, Hal or (fluoro) (mercapto) alk (oxy) yl, E is O or S; Y is --[CR(3).sub.2 ]n-, where R(3)=H or alkyl and n=1-4, X is H, Hal or alkyl and Z is Hal, NO.sub.2 or alk(yl)oxy, are described.The compounds I are used for treatment of disturbances in cardiac rhythm and prevention of sudden cardiac death caused by arrhythmia, and can therefore be used as antiarrhythmics. They are particularly suitable for those cases where arrhythmias are a consequence of a narrowing of a coronary vessel, such as angina pectoris or acute cardiac infarction.
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