发明授权
- 专利标题: Substituted benzenesulfonylureas and -thioureas- process for their preparation and their use as pharmaceuticals
- 专利标题(中): 取代苯磺酰脲和硫脲 - 其制备方法及其作为药物的用途
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申请号: US393027申请日: 1995-02-23
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公开(公告)号: US5574069A公开(公告)日: 1996-11-12
- 发明人: Heinrich Englert , Dieter Mania , Jens Hartung , Heinz Gogelein , Joachim Kaiser , Wolfgang Linz , David Wettlaufer
- 申请人: Heinrich Englert , Dieter Mania , Jens Hartung , Heinz Gogelein , Joachim Kaiser , Wolfgang Linz , David Wettlaufer
- 申请人地址: DEX Frankfurt am Main
- 专利权人: Hoechst Aktiengesellschaft
- 当前专利权人: Hoechst Aktiengesellschaft
- 当前专利权人地址: DEX Frankfurt am Main
- 优先权: DEX4305450.1 19930223
- 主分类号: A61K31/18
- IPC分类号: A61K31/18 ; A61K31/64 ; A61P9/00 ; A61P9/04 ; A61P9/10 ; C07C303/40 ; C07C311/46 ; C07C311/58 ; C07C323/67 ; C07C335/42 ; A61K31/17
摘要:
Benzenesulfonylureas and -thioureas of the formula I ##STR1## where R(1) is H or (fluoro)methyl, R(2) is H, Hal or (fluoro) (mercapto) alk (oxy) yl, E is O or S; Y is --[CR(3).sub.2 ]n-, where R(3)=H or alkyl and n=1-4, X is H, Hal or alkyl and Z is Hal, NO.sub.2 or alk(yl)oxy, are described.The compounds I are used for treatment of disturbances in cardiac rhythm and prevention of sudden cardiac death caused by arrhythmia, and can therefore be used as antiarrhythmics. They are particularly suitable for those cases where arrhythmias are a consequence of a narrowing of a coronary vessel, such as angina pectoris or acute cardiac infarction.
公开/授权文献
- USD275933S Container module 公开/授权日:1984-10-16
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