发明授权
US5576449A Preparation of 2-substituted but-2-ene-1,4-dial-4-acetals and novel
hemiacetals of glyoxal monoacetals
失效
2-取代的丁-2-烯-1,4-表面-4-缩醛的制备和乙二醛单缩醛的新半缩醛
- 专利标题: Preparation of 2-substituted but-2-ene-1,4-dial-4-acetals and novel hemiacetals of glyoxal monoacetals
- 专利标题(中): 2-取代的丁-2-烯-1,4-表面-4-缩醛的制备和乙二醛单缩醛的新半缩醛
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申请号: US314955申请日: 1994-09-29
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公开(公告)号: US5576449A公开(公告)日: 1996-11-19
- 发明人: J urgen Frank , Johann-Peter Melder , Franz Merger , Tom Witzel
- 申请人: J urgen Frank , Johann-Peter Melder , Franz Merger , Tom Witzel
- 申请人地址: DEX Ludwigshafen
- 专利权人: BASF Aktiengesellschaft
- 当前专利权人: BASF Aktiengesellschaft
- 当前专利权人地址: DEX Ludwigshafen
- 优先权: DEX4333239.0 19930930
- 主分类号: C07D319/06
- IPC分类号: C07D319/06
摘要:
The preparation of 2-substituted but-2-ene-1,4-dial-4-acetals of the formula I ##STR1## in which the substituents R.sup.1 to R.sup.4 stand for hydrogen or C.sub.1 -C.sub.6 aliphatic radicals, and R.sup.2 and R.sup.3 or R.sup.1 and R.sup.2 are in each case common members of an aliphatic 4-membered to 7-membered ring, which can contain a hetero atom, and R.sup.5 denotes an alkyl, alkenyl, or alkynyl radical having from 1 to 12 C atoms, which can be substituted by cycloaliphatic, aromatic or heterocyclic radicals or by hydroxy, ether, thioether, acyl, alkylamino, carboxy, or carbalkoxy groups, an optionally substituted aryl radical or an alkoxy, alkylthio, or acyloxy group, whereina) glyoxal is caused to react with a 1,3-propanediol of the formula II ##STR2## in aqueous solution in the presence of an acid to form a monoacetal of the formula III ##STR3## is neutralized, and if necessary the components more readily volatile than the monoacetal III are distilled off,b) the monoacetal III obtained is caused to react with an aldehyde R.sup.5 CH.sub.2 --CHO in the presence of from 0.01 to 10 mol %, based on glyoxal, of a catalyst mixture of a secondary amine and an acid to form an aldol of the formula IV ##STR4## the components which are more volatile than the aldol IV being distilled off if necessary, andc) the aldol IV is dehydrated in the presence of a water-eliminating agent to form the product I,and novel hemiacetals of glyoxal monoacetals.
公开/授权文献
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