发明授权
US5578589A Method for suppressing an immunoresponse with an estradiol
derivative-chlorambucil conjugate
失效
用雌二醇衍生物 - 苯丁酸氮芥配偶体抑制免疫应答的方法
- 专利标题： Method for suppressing an immunoresponse with an estradiol derivative-chlorambucil conjugate
- 专利标题（中）： 用雌二醇衍生物 - 苯丁酸氮芥配偶体抑制免疫应答的方法
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申请号： US440838申请日： 1995-05-15
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公开(公告)号： US5578589A公开(公告)日： 1996-11-26
- 发明人: Fumio Tamura , Tsuyoshi Saito , Satoshi Mitsuhashi , Tadahiro Matsudaira , Kiro Asano
- 申请人： Fumio Tamura , Tsuyoshi Saito , Satoshi Mitsuhashi , Tadahiro Matsudaira , Kiro Asano
- 申请人地址： JPX Tokyo
- 专利权人： Kureha Chemical Industry Co., Ltd.
- 当前专利权人： Kureha Chemical Industry Co., Ltd.
- 当前专利权人地址： JPX Tokyo
- 优先权： JPX4-177363 19920611
- 主分类号： A61K31/575
- IPC分类号： A61K31/575 ; A61P35/00 ; A61P37/06 ; C07J1/00 ; C07J41/00 ; A61K31/56
摘要：
The invention is drawn to a method for suppressing an immunoresponse in animals by administering an estradiol derivative-chlorambucil conjugate of the formula (I): ##STR1## wherein R.sup.1 is alkyl or alkoxyl of 1 to 4 carbon atoms; R.sup.2 is acyl, dansyl, or alkyl; R.sup.3, R.sup.4, and R.sup.5 independently are H, oxo, OH, or acyloxy; m is an integer of 1 to 3; and n is an integer of 0 to 3; provided that when n is 0, all of R.sup.3, R.sup.4, and R.sup.5 are not H at the same time, and at least one of R.sup.3, R.sup.4, and R.sup.5 is a group other than H and OH; and further, when n is 2 or 3, the groups R.sup.1 are the same or different.
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