Invention Grant
US5583235A Preparation of symmetrical and unsymmetrical
3,6-disubstituted-1,2-dithiins having antifungal activity
失效
具有抗真菌活性的对称和不对称3,6-二取代-1,2-二硫辛的制备
- Patent Title: Preparation of symmetrical and unsymmetrical 3,6-disubstituted-1,2-dithiins having antifungal activity
- Patent Title (中): 具有抗真菌活性的对称和不对称3,6-二取代-1,2-二硫辛的制备
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Application No.: US212096Application Date: 1994-03-11
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Publication No.: US5583235APublication Date: 1996-12-10
- Inventor: Donald E. Bierer , Jeffrey M. Dener , Thien V. Truong
- Applicant: Donald E. Bierer , Jeffrey M. Dener , Thien V. Truong
- Applicant Address: CA San Francisco
- Assignee: Shaman Pharmaceuticals, Inc.
- Current Assignee: Shaman Pharmaceuticals, Inc.
- Current Assignee Address: CA San Francisco
- Main IPC: C07D339/08
- IPC: C07D339/08 ; C07D409/06 ; C07D409/12 ; C07D409/14 ; C07D521/00 ; C07F7/18
Abstract:
The present invention provides an improved procedure for the preparation of 3,6-disubstituted-1,2-dithiin derivatives, especially unsymmetrical 1,2-dithiins. In addition, the process offers significant process, scaleup, and safety advantages over the previously reported synthetic processes. The compounds synthesized by this new process and described herein are particularly effective in treating fungal infections, especially those caused by Candida albicans, Cryptococcus neoformans, Aspergillus fumigatus, Trichophyton rubrum, Candida parapsilosis, Candida tropicalis, or Candida krusei.
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