发明授权
US5597722A Method for inactivating pathogens in compositions containing cells and
plasma using photoactive compounds and plasma protein reduction
失效
使用光敏化合物和血浆蛋白质还原来灭活含有细胞和血浆的组合物中病原体的方法
- 专利标题： Method for inactivating pathogens in compositions containing cells and plasma using photoactive compounds and plasma protein reduction
- 专利标题（中）： 使用光敏化合物和血浆蛋白质还原来灭活含有细胞和血浆的组合物中病原体的方法
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申请号： US274507申请日： 1994-07-13
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公开(公告)号： US5597722A公开(公告)日： 1997-01-28
- 发明人: John Chapman , Patricia M. Logan , Herma C. Neyndorff , Janice North
- 申请人： John Chapman , Patricia M. Logan , Herma C. Neyndorff , Janice North
- 申请人地址： IL Deerfield
- 专利权人： Baxter International Inc.
- 当前专利权人： Baxter International Inc.
- 当前专利权人地址： IL Deerfield
- 主分类号： A61L2/00
- IPC分类号： A61L2/00 ; C12N7/06 ; A01N1/02
摘要：
The present invention provides a method for inactivating pathogens in a body fluid, such as plasma, red cells, platelets, leukocytes, and bone marrow. The present invention minimizes adverse effects caused by the photosensitive agents while retaining the disinfecting activity of such agents and processes. Pursuant to the present invention, prior to irradiating a body fluid including a photoactive drug, the extracellular fluid, which in the case of blood components includes plasma proteins is at least substantially reduced. Additionally, after the irradiation process, the resultant body fluid is prevented from contacting additional extracellular fluid, e.g., plasma proteins, for a predefined period.