发明授权
US5606033A Displacement chromatography of proteins using low molecular weight
anionic displacers
失效
使用低分子量阴离子置换剂的蛋白质置换色谱法
- 专利标题： Displacement chromatography of proteins using low molecular weight anionic displacers
- 专利标题（中）： 使用低分子量阴离子置换剂的蛋白质置换色谱法
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申请号： US545457申请日： 1995-10-19
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公开(公告)号： US5606033A公开(公告)日： 1997-02-25
- 发明人: Steven M. Cramer , James A. Moore , Amitava Kundu , Yufei Li , Guhan Jayaraman
- 申请人： Steven M. Cramer , James A. Moore , Amitava Kundu , Yufei Li , Guhan Jayaraman
- 专利权人： Cramer; Steven M.,Moore; James A.,Kundu; Amitava,Li; Yufei,Jayaraman; Guhan
- 当前专利权人： Cramer; Steven M.,Moore; James A.,Kundu; Amitava,Li; Yufei,Jayaraman; Guhan
- 主分类号： C07C217/08
- IPC分类号： C07C217/08 ; B01D15/42 ; C07C215/40 ; C07K1/18 ; G01N30/02 ; C07K1/14 ; C07K1/16
摘要：
A method for the purification of proteins by displacement chromatography on ion exchange media using low molecular weight displacers is disclosed. Several classes of low molecular weight anionic species are exemplified, including aromatic rings having sulfonic acid or carboxylic acid moieties attached thereon, sulfated sugar derivatives, anionic antibiotics, and dendrimeric polymers. Novel compounds useful as displacers are dendrimers of formula ##STR1## wherein R.sup.1 is lower alkyl, n is 2 to 6 and similar dendritic polymers based thereon.
公开/授权文献
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