发明授权
US5608102A Process for the preparation of .beta.-phenylisoserine and its analogues
失效
制备β-苯基异丝氨酸及其类似物的方法
- 专利标题： Process for the preparation of .beta.-phenylisoserine and its analogues
- 专利标题（中）： 制备β-苯基异丝氨酸及其类似物的方法
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申请号： US295677申请日： 1994-09-26
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公开(公告)号： US5608102A公开(公告)日： 1997-03-04
- 发明人: Jean-Dominique Bourzat , Alain Commer.cedilla.on
- 申请人： Jean-Dominique Bourzat , Alain Commer.cedilla.on
- 申请人地址： FRX Antony
- 专利权人： Rhone-Poulenc Rorer S.A.
- 当前专利权人： Rhone-Poulenc Rorer S.A.
- 当前专利权人地址： FRX Antony
- 优先权： FRX9202821 19920310
- 主分类号： C07C227/18
- IPC分类号： C07C227/18 ; C07C227/22 ; C07C229/34 ; C07D205/08 ; C07D305/14 ; C07D205/02
摘要：
This invention relates to a method for preparing .beta.-phenylisoserine and analogues thereof having general formula (I) ##STR1## from an aromatic aldehyde and an .alpha.-methylarylamine-S, and through a lactam of general formula (II) as described herein. The acids of general formula (I) (R.dbd.H) may be used to prepare taxane derivatives having remarkable antitumoral and antileukaemic activity.
公开/授权文献
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