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    METHODS AND SYSTEM FOR STIMULATING ROOT EXUDATION IN PLANTS
    2.
    发明申请
    METHODS AND SYSTEM FOR STIMULATING ROOT EXUDATION IN PLANTS 有权

    公开(公告)号：US20210007363A1

    公开(公告)日：2021-01-14

    申请号：US17040227

    申请日：2019-03-21

    Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD

    Inventor： Asaph AHARONI ,  Elisa KORENBLUM

    IPC: A01N63/38 ,  C07D305/14 ,  C07J17/00 ,  A01N63/20 ,  A01G29/00

    Abstract: Provided is a plant exudate, methods for obtaining a plant exudate by inducing the plant to secrete an exudate and systems for the collection of a plant exudate which include: one or more plant container including at least two discrete compartments each configured to accommodate a split root of a plant, the compartments being a root stimulating compartment including one or more input being in fluid communication with at least a source of a plant root stimulant, and a root exudate harvesting compartment, and a root exudate collection compartment in fluid communication with the root exudate harvesting compartment.

    ISOCYANATES, DERIVATIVES, AND PROCESSES FOR PRODUCING THE SAME
    3.
    发明申请
    ISOCYANATES, DERIVATIVES, AND PROCESSES FOR PRODUCING THE SAME 审中-公开

    公开(公告)号：US20200331876A1

    公开(公告)日：2020-10-22

    申请号：US16753591

    申请日：2018-10-04

    Applicant: Novomer, Inc.

    Inventor： Oleg Kulikov ,  Sadesh H. Sookraj ,  Utpal Mahendra Vakil ,  Matthew Goodrich

    IPC: C07D305/12 ,  C07D305/08 ,  C07D307/20 ,  C07D407/12 ,  C07D305/14 ,  C08G18/09 ,  C08L75/04

    Abstract: The present invention is directed to processes for producing isocyanates and isocyanate derivatives from epoxide and carbon monoxide reagents. In preferred embodiments, the processes include a step for providing carbonylation of an epoxide reagent with a carbon monoxide reagent to produce a beta-lactone intermediate. In certain preferred embodiments, further carbonylation of a beta-lactone intermediate produces a succinic anhydride intermediate. The processes of the present invention include steps for rearranging beta-lactone intermediates and/or succinic anhydride intermediates to produce isocyanate products and/or isocyanate derivatives. In certain preferred embodiments, the isocyanate products may be copolymerized with polyol oligomers to provide polyurethane products.

    Processes for producing beta-lactone with heterogenous catalysts
    4.
    发明授权
    Processes for producing beta-lactone with heterogenous catalysts 有权

    公开(公告)号：US10590099B1

    公开(公告)日：2020-03-17

    申请号：US15674453

    申请日：2017-08-10

    Applicant: Novomer, Inc.

    Inventor： Sadesh H. Sookraj

    IPC: C07D305/12 ,  C07D305/14 ,  C07D407/12 ,  C07D407/06 ,  B01J31/18 ,  B01J37/08 ,  B01J31/20 ,  B01J37/04 ,  B01J37/02

    Abstract: The present invention is directed to processes from producing beta-lactone and beta-lactone derivatives using heterogenous catalysts. In preferred embodiments of the present invention, the processes comprise the steps: passing a feed stream comprising an epoxide reagent and a carbon monoxide reagent to a reaction zone; contacting the epoxide reagent and the carbon monoxide reagent with a heterogenous catalyst to produce a beta-lactone product in the reaction zone; and removing the beta-lactone product from the reaction zone. In preferred embodiments, the heterogenous catalyst comprises a solid support containing a cationic Lewis acid functional group and a metal carbonyl compound comprising at least one of anionic metal carbonyl compound or a neutral metal carbonyl compound. In certain preferred embodiments, the epoxide reagent and carbon monoxide reagent have a biobased content.

    9,10-Alpha,Alpha-OH-Taxane Analogs and Methods for Production Thereof
    5.
    发明申请
    9,10-Alpha,Alpha-OH-Taxane Analogs and Methods for Production Thereof 审中-公开

    公开(公告)号：US20190142784A1

    公开(公告)日：2019-05-16

    申请号：US16247425

    申请日：2019-01-14

    Applicant: Tapestry Pharmaceuticals, Inc.

    Inventor： Jan Zygmunt ,  James Ferrara ,  James D. McChesney

    IPC: A61K31/337 ,  C07D409/12 ,  A61K31/357 ,  C07D305/14 ,  C07D493/08

    Abstract: Provided herein are compounds, compositions containing the compounds, and methods for the treatment of cancer in a cancer patient. In particular, the compounds are made by a process comprising treating a first compound represented by either Formula G′ or Formula M′: with a second compound of generalized formula R8R9C(OCH3)2 and an acid selected from the group consisting of camphor sulfonic acid (CSA), p-toluene sulfonic acid (PTSA), hydrochloric acid (HCl) and acetic acid (AcOH), wherein R1 and R2 are each selected from H, an alkyl group, an olefinic group, an aromatic group, an O-alkyl group, an O-olefinic group, or an O-aromatic group; R7 is an alkyl group, an olefinic group, or an aromatic group; P1 is a hydroxyl protecting group; P5 is H or an acid labile protecting group at the 7-O position; R8 is H, alkyl group, olefinic or aromatic group; and R9 is: H, alkyl group, olefinic or aromatic or is as defined in the specification.

    Taxanes compounds, preparation method therefor, and uses thereof
    6.
    发明授权
    Taxanes compounds, preparation method therefor, and uses thereof 有权

    公开(公告)号：US10253007B2

    公开(公告)日：2019-04-09

    申请号：US15038264

    申请日：2014-11-21

    Applicant: Jiangsu Tasly Diyi Pharmaceutical Co., Ltd.

    Inventor： Wei Zhou ,  Yunrong Jing ,  Yongfeng Wang ,  Guocheng Wang

    IPC: A61K31/337 ,  C07D305/14 ,  C07D405/12 ,  C07C271/22 ,  C07C233/87

    Abstract: The present invention provides taxanes compounds with a formula (I) or formula (II) structure, a method for preparing the compounds, as well as the use of the compositions containing the compounds, pharmaceutically acceptable salts and solvates thereof as active ingredients in manufacturing oral antitumor medicaments, In formula (I), R1 is —COR6, —COOR6 or —CONR7aR7b; R2 is a C1-C6 alkyl, a C1-C6 alkenyl, a substituted hydrocarbon group, a heterocyclic group, an aromatic group or a substituted aromatic group; R3 is —OR6, —OCOOR6, —OCOSR6 or —OCONR7aR7b; R4 is —OR6, —OCOOR6, —OCOSR6, —OCONR7aR7b or H; wherein, R6 is a C1-C6 alkyl, a C1-C6 alkenyl, a C1-C6 alkynyl, a substituted hydrocarbon group, an aromatic group or a heterocyclic group; R7a and R7b are respectively hydrogen, a hydrocarbon group, a substituted hydrocarbon group or a heterocyclic group. In formula (II), R1 is —COR6 or —COOR6; R2 is an aromatic group; R3 is —OR6; wherein, R6 is a C1-C6 alkyl, a C1-C6 alkenyl, a C1-C6 alkynyl, a substituted hydrocarbon group, an aromatic group or a heterocyclic group.

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