发明授权
- 专利标题: Low toxicity drug-lipid systems
- 专利标题(中): 低毒性药物 - 脂质体系
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申请号: US430699申请日: 1995-04-28
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公开(公告)号: US5616334A公开(公告)日: 1997-04-01
- 发明人: Andrew S. Janoff , Lawrence Boni , Thomas D. Madden , Pieter R. Cullis , Robert P. Lenk , John J. Kearns , Anthony G. Durning , Robert Klimchak , Joel Portnoff
- 申请人: Andrew S. Janoff , Lawrence Boni , Thomas D. Madden , Pieter R. Cullis , Robert P. Lenk , John J. Kearns , Anthony G. Durning , Robert Klimchak , Joel Portnoff
- 申请人地址: NJ Princeton
- 专利权人: The Liposome Company, Inc.
- 当前专利权人: The Liposome Company, Inc.
- 当前专利权人地址: NJ Princeton
- 主分类号: A61K9/127
- IPC分类号: A61K9/127 ; A61K9/16 ; A01N25/32 ; A01N57/26 ; A61K31/685
摘要:
Methods and compositions are described for nonliposomal lipid complexes in association with toxic hydrophobic drugs such as the polyene antibiotic amphotericin B. Lipid compositions are preferably a combination of the phospholipids dimyristoylphosphatidylcholine (DMPC) and dimyristoylphosphatidylglycerol (DMPG) in about a 7:3 mole ratio. The lipid complexes contain a bioactive agent, and may be made by a number of procedures, at high drug:lipid ratios. These compositions of high drug:lipid complexes (HDLCs) may be administered to mammals such as humans for the treatment of infections, with substantially equivalent or greater efficacy and reduced drug toxicities as compared to the drugs in their free form. Also disclosed is a novel liposome-loading procedure, which may also be used in the formation of the HDLCs.
公开/授权文献
- US5052636A Damped filament dispenser 公开/授权日:1991-10-01
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