Invention Grant
- Patent Title: Tissue plasminogen activator having zymogenic or fibrin specific properties
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Application No.: US422736Application Date: 1995-04-14
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Publication No.: US5616486APublication Date: 1997-04-01
- Inventor: Stephen Anderson , William F. Bennett , David Botstein , Deborah L. Higgins , Nicholas F. Paoni , Mark J. Zoller
- Applicant: Stephen Anderson , William F. Bennett , David Botstein , Deborah L. Higgins , Nicholas F. Paoni , Mark J. Zoller
- Applicant Address: CA San Francisco
- Assignee: Genentech, Inc.
- Current Assignee: Genentech, Inc.
- Current Assignee Address: CA San Francisco
- Main IPC: A61K38/00
- IPC: A61K38/00 ; A61K38/48 ; C07H21/04 ; C12N1/21 ; C12N5/10 ; C12N9/64 ; C12N9/72 ; C12N15/55 ; C12N15/58 ; C12N15/63 ; C12N15/70 ; C12N15/86
Abstract:
Tissue plasminogen activator (t-PA) zymogens and variants are prepared, including a fibrinolytically active variant of t-PA that has an amino acid alteration at a site within the protease domain of t-PA as compared with the corresponding wild-type t-PA, which alteration renders the variant zymogenic in the presence of plasmin-degraded fibrinogen, and/or fibrin (or plasma clot) specific, as compared to the corresponding wild-type t-PA. DNA sequences can be prepared that encode the zymogens and variants, as well as expression vectors incorporating the DNA sequences, and host cells transformed with the expression vectors. The zymogens and variants may be used in a pharmaceutical preparation to treat a vascular disease or condition or to prevent fibrin deposition or adhesion formation or reformation in mammals.
Public/Granted literature
- US5070581A Protective device for billfolds and wallets Public/Granted day:1991-12-10
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