The present invention provides endoscopic instrumentation and surgical techniques especially useful for accessing and removing at least a portion of an intervertebral disc. Instrumentation includes tissue spreaders and cutting instruments. In particular, the tissue spreading instruments include instruments for spreading pre-sacral tissue such as fascia and for spreading adjacent vertebrae to facilitate access to the intervertebral disc. Endoscopic cutting instruments deliver a cutting blade in a sheathed position to the site of the disc nucleus followed by deployment to remove portions of the disc nucleus.