发明授权
- 专利标题： Lipid-polymer conjugates and liposomes
- 专利标题（中）： 脂质 - 聚合物共轭物和脂质体
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申请号： US317723申请日： 1994-10-04
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公开(公告)号： US5631018A公开(公告)日： 1997-05-20
- 发明人: Samuel Zalipsky , Martin C. Woodle , Danilo D. Lasic , Francis J. Martin
- 申请人： Samuel Zalipsky , Martin C. Woodle , Danilo D. Lasic , Francis J. Martin
- 申请人地址： CA Menlo Park
- 专利权人： Sequus Pharmaceuticals, Inc.
- 当前专利权人： Sequus Pharmaceuticals, Inc.
- 当前专利权人地址： CA Menlo Park
- 主分类号： A61K9/127
- IPC分类号： A61K9/127 ; A61K47/32 ; A61K47/34 ; A61K47/48 ; C08F289/00 ; C08G69/10 ; C08G69/48 ; C08G73/02 ; C08G73/10 ; C08G81/02
摘要：
A lipid-polymer conjugate for use in forming long-circulating liposomes is disclosed. The conjugate includes a vesicle-forming lipid having covalently attached to its polar head group, one of the polymers: polyvinylpyrrolidone, polyvinylmethylether, polyhydroxypropyl methacrylate, polyhydroxypropylmethacrylamide, polyhydroxyethyl acrylate, polymethacrylamide, polydimethylacrylamide, polymethyloxazoline, polyethyloxazoline, polyhydroxyethyloxazoline, polyhydroxypropyloxazoline, or polyaspartamide. A method for preparing liposomes containing the lipid-polymer conjugate is also disclosed.
公开/授权文献
- US4916342A Rotary actuator 公开/授权日：1990-04-10
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