发明授权
US5633227A Secretory leukocyte protease inhibitor as an inhibitor of tryptase
失效
分泌型白细胞蛋白酶抑制剂作为类胰蛋白酶抑制剂
- 专利标题： Secretory leukocyte protease inhibitor as an inhibitor of tryptase
- 专利标题（中）： 分泌型白细胞蛋白酶抑制剂作为类胰蛋白酶抑制剂
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申请号： US304051申请日： 1994-09-12
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公开(公告)号： US5633227A公开(公告)日： 1997-05-27
- 发明人: Daniel K. Muller , Elise Brownell , Katherine A. Delaria
- 申请人： Daniel K. Muller , Elise Brownell , Katherine A. Delaria
- 申请人地址： CT West Haven
- 专利权人： Miles, Inc.
- 当前专利权人： Miles, Inc.
- 当前专利权人地址： CT West Haven
- 主分类号： C12N15/09
- IPC分类号： C12N15/09 ; A61K35/76 ; A61K38/00 ; A61K38/55 ; A61K48/00 ; A61P11/00 ; A61P27/16 ; A61P37/08 ; A61P43/00 ; C07D277/24 ; C07K7/06 ; C07K14/575 ; C07K14/81 ; C12N9/64 ; C12N9/99 ; A61K38/57
摘要：
This invention concerns methods of treating mast-cell mediated conditions in mammals, the methods comprising administering to the mammals pharmacologically active fragments or muteins of SLPI; methods of treating asthma or allergic rhinitis in mammals, the methods comprising administering to the mammals SLPI or pharmacologically active fragments or muteins thereof; methods for inhibiting tryptase; methods for identifying inhibitors of tryptase; and certain fragments and muteins of SLPI.
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