发明授权
US5635505A 1,4-benzoxazine-2-acetic acid compound, method for production thereof
and use thereof
失效
1,4-苯并恶嗪-2-乙酸化合物，其制备方法和用途
- 专利标题： 1,4-benzoxazine-2-acetic acid compound, method for production thereof and use thereof
- 专利标题（中）： 1,4-苯并恶嗪-2-乙酸化合物，其制备方法和用途
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申请号： US666326申请日： 1996-07-03
-
公开(公告)号： US5635505A公开(公告)日： 1997-06-03
- 发明人: Takahiro Kumonaka , Takema Hase , Tomoji Aotsuka , Toshio Kurihara , Yoshiyuki Nakamura , Tetsuo Matsui , Hiromichi Ishikawa , Fujio Kobayashi
- 申请人： Takahiro Kumonaka , Takema Hase , Tomoji Aotsuka , Toshio Kurihara , Yoshiyuki Nakamura , Tetsuo Matsui , Hiromichi Ishikawa , Fujio Kobayashi
- 申请人地址： JPX Osaka JPX Osaka
- 专利权人： Senju Pharmaceutical Co., Ltd.,The Green Cross Corporation
- 当前专利权人： Senju Pharmaceutical Co., Ltd.,The Green Cross Corporation
- 当前专利权人地址： JPX Osaka JPX Osaka
- 主分类号： C07D417/06
- IPC分类号： C07D417/06 ; A61K31/535
摘要：
A 1,4-benzoxazine-2-acetic acid compound of the formula (I) ##STR1## wherein each symbol is as defined in the specification, a pharmaceutically acceptable salt thereof, a method for production thereof, and a pharmaceutical composition, an aldose reductase inhibitor and an agent for the prevention and/or treatment of the complications of diabetes, which contain the same. The compound (I) of the present invention and pharmaceutically acceptable salts thereof have aldose reductase inhibitory action and are superior in safety. Accordingly, they are useful as an agent for the prevention and/or treatment of the complications of diabetes such as faulty union of corneal injury, cataract, neurosis, retinopathy and nephropathy, in particular, cataract and neurosis.
公开/授权文献
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