发明授权
US5637736A Process for preparing 1-bromoalkylbenzene derivatives and intermediates
thereof
失效
制备1-溴烷基苯衍生物的方法及其中间体
- 专利标题: Process for preparing 1-bromoalkylbenzene derivatives and intermediates thereof
- 专利标题(中): 制备1-溴烷基苯衍生物的方法及其中间体
-
申请号: US286411申请日: 1994-08-05
-
公开(公告)号: US5637736A公开(公告)日: 1997-06-10
- 发明人: Hiroaki Fujishima , Yasunobu Miyamoto , Masayoshi Minai , Tsutomu Matsumoto , Hideki Ushio , Takayuki Higashii
- 申请人: Hiroaki Fujishima , Yasunobu Miyamoto , Masayoshi Minai , Tsutomu Matsumoto , Hideki Ushio , Takayuki Higashii
- 申请人地址: JPX Osaka
- 专利权人: Sumitomo Chemical Company, Limited
- 当前专利权人: Sumitomo Chemical Company, Limited
- 当前专利权人地址: JPX Osaka
- 优先权: JPX5-196039 19930806; JPX6-001711 19940112; JPX6-002492 19940114
- 主分类号: C07C15/44
- IPC分类号: C07C15/44 ; C07C17/08 ; C07C17/087 ; C07C17/26 ; C07C41/22 ; C07F3/02 ; C07D319/14
摘要:
A 1-bromoalkylbenzene derivative is prepared by reacting a phenylalkene derivative with hydrogen bromide in the presence of a non-polar solvent. The phenylalkene derivative is prepared by reacting an alkenyl halide with metal magnesium to form a Grignard reagent, and then reacting the Grignard reagent with a benzyl halide derivative. An allyl Grignard reagent is prepared by reacting continuously an allyl halide derivative with metal magnesium in an organic solvent, in which the allyl halide derivative and metal magnesium are continuously added to the reaction system and the allyl Grignard reagent formed is continuously removed from the reaction system. The processes provide the intended compounds in high yields, high selectivities and high purities.
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