A jaw assembly for an endoscopic bioptome includes a pair of opposed end effectors having resilient arms formed from a super-elastic metal. The distal ends of the resilient arms terminate in end effector jaw cups which are also preferably formed from super-elastic metal, while the proximal portions of the resilient arms include angled portions which urge the jaw cups away from each other. The jaw cups are brought together into a biting action by a cylinder having a sharp distal edge which moves relative to over the arms of the end effectors. As the resilient arms are formed from a superelastic metal, they exhibit very high resiliency and durability even after numerous uses. Several embodiments of jaws and different ways of coupling the jaws to the distal end of the bioptome are disclosed.