The present invention relates to cement bead for orthopaedic surgery and its manufacturing process, embodying the cement beads for orthopaedic surgery manufactured from the mixture of antibiotics and cement which can be implanted into the dead space produced after the first saucerization on a patient with chronic osteomyelitis.Thus, the present invention is designed to obtain direct bactericidal effect by implanting the cement beads into a dead space, produced after the first saucerization, and to reduce the toxicity of systemic antibiotics and the risk of recurrence by mixing broad spectrum antibiotics, being thermally stable and sensitive to many microorganisms, where it comprises; mixing Ticarcillin of 5-10 g, Cefazolin of 5-10 g, Tobramicin of 5-10 g and Vancomycin of 5 g; homogenizing 20-25 cc of antibiotic mixed powder with 120 cc of powder cement; mixing this homogenized powder with 20-30 cc of liquid cement; cutting it in the form of rosary in the process of hardening; running a needle and thread through them to make the chain of antibiotic-mixed cement beads.