发明授权
- 专利标题: BPI-immunoglobulin fusion proteins
- 专利标题(中): BPI免疫球蛋白融合蛋白
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申请号: US64693申请日: 1993-05-19
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公开(公告)号: US5643570A公开(公告)日: 1997-07-01
- 发明人: Georgia Theofan , Lynn S. Grinna , Arnold Horwitz
- 申请人: Georgia Theofan , Lynn S. Grinna , Arnold Horwitz
- 申请人地址: CA Berkeley
- 专利权人: XOMA Corporation
- 当前专利权人: XOMA Corporation
- 当前专利权人地址: CA Berkeley
- 主分类号: A61K38/00
- IPC分类号: A61K38/00 ; C07K14/47 ; C07K19/00 ; C12N1/21 ; C12N15/12 ; C12N15/13 ; C12N15/63 ; C12N15/85 ; C12P21/00 ; A61K39/395 ; C12N15/00
摘要:
Disclosed are novel hybrid fusion proteins comprising at their amino terminus, bactericidal/permeability-increasing protein or a biologically active fragment thereof and, at their carboxy terminus, at least one immunoglobulin heavy chain constant domain useful in treating bacterial infection. Also disclosed are DNA sequences encoding such proteins, recombinant methods for production of the proteins, and pharmaceutical preparations containing the recombinant products.
公开/授权文献
- USD391513S Hollow barrier 公开/授权日:1998-03-03