发明授权
- 专利标题： Quinuclidinyloxy-isoxazole compounds and their therapeutic uses
- 专利标题（中）： 喹喔啉氧基 - 异恶唑化合物及其治疗用途
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申请号： US937445申请日： 1992-08-27
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公开(公告)号： US5643923A公开(公告)日： 1997-07-01
- 发明人: Mitsuo Nagano , Takeo Kobayashi , Junichi Sakai , Masao Kozuka , Nobuyoshi Iwata , Yoshiko Kubo
- 申请人： Mitsuo Nagano , Takeo Kobayashi , Junichi Sakai , Masao Kozuka , Nobuyoshi Iwata , Yoshiko Kubo
- 申请人地址： JPX Tokyo
- 专利权人： Sankyo Company, Limited
- 当前专利权人： Sankyo Company, Limited
- 当前专利权人地址： JPX Tokyo
- 优先权： JPX2-119754 19900511; JPX2-216519 19900817; JPX2-278489 19901017
- 主分类号： A61K31/445
- IPC分类号： A61K31/445 ; A61K31/42 ; A61P25/28 ; C07D261/12 ; C07D261/20 ; C07D413/04 ; C07D413/12 ; C07D413/14 ; C07D453/02 ; A61K31/44 ; C07D261/04
摘要：
Compounds of formula (I): ##STR1## wherein R.sup.1 is hydrogen, halogen or alkyl; R.sup.2 is hydrogen, alkyl, optionally substituted phenyl or a heterocycle; or R.sup.1 and R.sup.2 together form a group of formula --CR.sup.4 .dbd.CR.sup.5 --CR.sup.6 .dbd.CR.sup.7 --, where R.sup.4, R.sup.5, R.sup.6 and R.sup.7 are hydrogen, halogen, alkyl group, alkoxy, halomethyl, alkylamino, dialkylamino, hydroxy, nitro, aliphatic carboxylic acylamino or amino; and R.sup.3 is piperidyl, substituted piperidyl or quinuclidinyl. The compounds are useful in the treatment and prophylaxis of cognitive disorders, notably senile dementia, including Alzheimer's disease. Processes for preparing the compounds are also provided.
公开/授权文献
- US4210252A Angleworm storage box 公开/授权日：1980-07-01
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