Invention Grant
US5652359A Oligonucleotides containing n-methyl thiolated bases having antiviral
activity
失效
含有具有抗病毒活性的正甲基硫醇化碱基的寡核苷酸
- Patent Title: Oligonucleotides containing n-methyl thiolated bases having antiviral activity
- Patent Title (中): 含有具有抗病毒活性的正甲基硫醇化碱基的寡核苷酸
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Application No.: US162590Application Date: 1993-12-02
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Publication No.: US5652359APublication Date: 1997-07-29
- Inventor: Rich B. Meyer, Jr. , Alexander A. Gall , Arthur D. Broom
- Applicant: Rich B. Meyer, Jr. , Alexander A. Gall , Arthur D. Broom
- Applicant Address: DC Washington
- Assignee: Epoch Pharmaceuticals, Inc.
- Current Assignee: Epoch Pharmaceuticals, Inc.
- Current Assignee Address: DC Washington
- Main IPC: C07H21/00
- IPC: C07H21/00 ; C07H21/02 ; A61K31/70
Abstract:
Oligonucleotides containing 1-N-alkyl-6-thiopurine, 3-N-alkyl-4-thiopyrimidine and 5-N-alkyl-4-thiopyrazolopyrimidine bases and the corresponding 2'-O-alkylated or allylated nucleotides demonstrate potent antiviral activity in several assays, including the human immunodeficiency virus reverse transcriptase enzyme assay. The oligonucleotides of the invention contain approximately 5 to 99 nucleotide units, and may include, in addition to the above-noted N-alkylated and thiolated heterocyclic bases, the naturally occurring pyrimidine and purine bases.
Public/Granted literature
- US6080412A Pharmaceutical microencapsulation Public/Granted day:2000-06-27
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