Invention Grant
- Patent Title: Cooperative combinations of ligands contained within a matrix
- Patent Title (中): 包含在基质中的配体的合作组合
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Application No.: US347942Application Date: 1994-11-30
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Publication No.: US5654267APublication Date: 1997-08-05
- Inventor: Kristiina Vuori , Erkki I. Ruoslahti
- Applicant: Kristiina Vuori , Erkki I. Ruoslahti
- Applicant Address: CA La Jolla
- Assignee: La Jolla Cancer Research Center
- Current Assignee: La Jolla Cancer Research Center
- Current Assignee Address: CA La Jolla
- Main IPC: A61K38/00
- IPC: A61K38/00 ; A61K38/22 ; A61K38/28 ; A61K38/39 ; A61K47/48 ; A61L26/00 ; A61P17/00 ; C07K7/06 ; C07K7/08 ; C07K14/49 ; C07K14/54 ; C07K14/62 ; C07K14/65 ; C07K14/78 ; C07K17/02 ; C07K17/10 ; C12N5/00
Abstract:
The present invention provides compositions and methods for promoting cell migration and tissue regeneration. The composition contains a ligand for the .alpha..sub.v .beta..sub.3 integrin and a ligand for the insulin receptor, the PDGF receptor, the IL-4 receptor, or the IGF receptor, combined in a matrix. The combination of .alpha..sub.v .beta..sub.3 ligand and growth factor produces an unexpected synergistic effect in enhancing wound healing compared with the effect of each component separately. The present invention also provides a method of wound healing and a method of inducing tissue regeneration by applying the compositions of the present invention to the site of the wound.
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