发明授权
US5658939A Methionine sulfone and S-substituted cysteine sulfone derivatives as
enzyme inhibitors
失效
甲硫氨酸砜和S-取代的半胱氨酸砜衍生物作为酶抑制剂
- 专利标题： Methionine sulfone and S-substituted cysteine sulfone derivatives as enzyme inhibitors
- 专利标题（中）： 甲硫氨酸砜和S-取代的半胱氨酸砜衍生物作为酶抑制剂
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申请号： US423584申请日： 1995-04-18
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公开(公告)号： US5658939A公开(公告)日： 1997-08-19
- 发明人: Matthew Mark Abelman , Robert John Ardecky , Ruth Foelsche Nutt
- 申请人： Matthew Mark Abelman , Robert John Ardecky , Ruth Foelsche Nutt
- 申请人地址： CA San Diego
- 专利权人： Corvas International Inc.
- 当前专利权人： Corvas International Inc.
- 当前专利权人地址： CA San Diego
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; A61P7/02 ; C07K5/06 ; C07K5/062 ; C07K5/072 ; C07K5/078 ; A61K31/40 ; A61K31/41 ; C07D403/12 ; C07D403/14
摘要：
This invention relates to compounds which inhibit thrombin or factor Xa. The compounds contain an aldehyde functionality and a methionine sulfone or S-substituted cysteine sulfone residue. The compounds and their pharmaceutical compositions are useful for preventing thrombosis in mammals which are suspected of having a condition characterized by abnormal thrombosis.
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