发明授权
- 专利标题: Benzopyran compounds as 5HT.sub.2C receptor antagonists
- 专利标题(中): 苯并吡喃化合物作为5HT2C受体拮抗剂
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申请号: US498217申请日: 1995-07-05
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公开(公告)号: US5663191A公开(公告)日: 1997-09-02
- 发明人: Gilbert Lavielle , Thierry Dubuffet , Mark Millan , Adrian Newman-Tancredi
- 申请人: Gilbert Lavielle , Thierry Dubuffet , Mark Millan , Adrian Newman-Tancredi
- 申请人地址: FRX Courbevoie
- 专利权人: Adir Et Compagnie
- 当前专利权人: Adir Et Compagnie
- 当前专利权人地址: FRX Courbevoie
- 优先权: FRX94.08328 19940706
- 主分类号: A61K31/40
- IPC分类号: A61K31/40 ; A61K31/435 ; A61P9/00 ; A61P13/02 ; A61P15/00 ; A61P25/04 ; A61P25/18 ; A61P25/20 ; A61P25/24 ; A61P25/26 ; A61P25/30 ; A61P43/00 ; C07D491/04 ; C07D491/052
摘要:
Compounds of formula (I): ##STR1## in which: n represents 1 or 2,R.sub.1 represents hydrogen or alkyl, benzyl, acetyl, benzoyl, allyl, pyridinecarbonyl, pyridinemethyl, acylaminoalkyl (optionally substituted), pyridineaminocarbonyl, phthalimidoalkyl, thiochromanyloxyalkyl or (benzodioxanyloxy)alkyl,R.sub.2, R.sub.3 or R.sub.4, which may be identical or different, represent hydrogen or halogen or alkyl, alkoxy, hydroxyl, acetyl, aminocarbonyl, aminomethyl, cyano, nitro, amino, phenyl (which may or may not be substituted), furyl, pyridinyl, thienyl or pyridyl, or alternatively, when they are located on adjacent carbons, R.sub.2 and R.sub.3 form, with the carbon atoms which bear them, a furan or phenyl ring,the isomers thereof and the addition salts thereof with a pharmaceutically acceptable acid, and medicinal products containing the same are useful for the treatment of diseases requiring a ligand to the 5-HT.sub.2C receptors.