发明授权
- 专利标题： Receptor specific atrial natriuretic peptides
- 专利标题（中）： 受体特异性心房利钠肽
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申请号： US451240申请日： 1995-05-25
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公开(公告)号： US5665704A公开(公告)日： 1997-09-09
- 发明人: David Lowe , Brian C. Cunningham , David Oare , Robert S. McDowell , John Burnier
- 申请人： David Lowe , Brian C. Cunningham , David Oare , Robert S. McDowell , John Burnier
- 申请人地址： CA South San Francisco
- 专利权人： Genentech, Inc.
- 当前专利权人： Genentech, Inc.
- 当前专利权人地址： CA South San Francisco
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; C07K14/58
摘要：
Human receptor selective atrial natriuretic factor variants containing various substitutions, especially G16R, show equal potency and binding affinity for the human A-receptor but have decreased affinity for the human clearance or C-receptor. These ANF variants have natriuretic, diuretic and vasorelaxant activity but have increased metabolic stability, making them suitable for treating congestive heart failure, acute kidney failure and renal hypertension.
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