发明授权
- 专利标题: Methods of treating microbial infections
- 专利标题(中): 治疗微生物感染的方法
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申请号: US477876申请日: 1995-06-07
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公开(公告)号: US5668167A公开(公告)日: 1997-09-16
- 发明人: Richard R. Tidwell , James E. Hall , David W. Boykin , Christine C. Dykstra , John Perfect , Byron L. Blagburn
- 申请人: Richard R. Tidwell , James E. Hall , David W. Boykin , Christine C. Dykstra , John Perfect , Byron L. Blagburn
- 申请人地址: NC Durham AL Auburn GA Atlanta NC Chapel Hill
- 专利权人: Duke University,Auburn University,Georgia State University,The University of North Carolina at Chapel Hill
- 当前专利权人: Duke University,Auburn University,Georgia State University,The University of North Carolina at Chapel Hill
- 当前专利权人地址: NC Durham AL Auburn GA Atlanta NC Chapel Hill
- 主分类号: A61K31/40
- IPC分类号: A61K31/40 ; A61K31/403 ; A61K31/415 ; A61K31/4178 ; A61K31/505 ; A61P11/00 ; A61P31/00 ; C07D209/86 ; C07D209/88 ; C07D403/14
摘要:
The present invention provides methods for treating Cryptococcus neoformans, Cryptosporidium parvum, and Candida albicans in a subject in need of such treatment. The methods comprises administering to the subject a compound of Formula I: ##STR1## wherein: X is located in the para or meta positions and is loweralkyl, loweralkoxy, alkoxyalkyl, hydroxyalkyl, aminoalkyl, alkylaminoalkyl, cycloalkyl, aryl, alkylaryl, halogen, or ##STR2## wherein: each R.sub.2 is independently selected from the group consisting of H, loweralkyl, alkoxyalkyl, hydroxyalkyl, aminoalkyl, alkylaminoalkyl, cycloalkyl, aryl, or alkylaryl or two R.sub.2 groups together represent C.sub.2 -C.sub.10 alkylene, or two R.sub.2 groups together represent ##STR3## wherein m is from 1-3 and R.sub.4 is H, ##STR4## or --CONHR.sub.5 NR.sub.6 R.sub.7, whereinR.sub.5 is loweralkyl, R.sub.6 and R.sub.7 are each independently selected from the group consisting of H and lower alkyl; each R.sub.8 is independently selected from the group consisting of H, loweralkyl, alkoxyalkyl, hydroxyalkyl, aminoalkyl, alkylaminoalkyl, cycloalkyl, aryl, or alkylaryl, or two R.sub.8 groups together represent C.sub.2 -C.sub.10 alkylene; R.sub.9 is H, hydroxy, loweralkyl, alkoxyalkyl, hydroxyalkyl, aminoalkyl, alkylaminoalkyl, cycloalkyl, aryl, or alkylaryl;R.sub.3 is H, hydroxy, loweralkyl, alkoxyalkyl, hydroxyalkyl, aminoalkyl, alkylaminoalkyl, cycloalkyl, aryl, or alkylaryl;R.sub.1 is H, loweralkyl, alkoxyalkyl, hydroxyalkyl, aminoalkyl, alkylaminoalkyl, cycloalkyl, aryl, alkylaryl, or halogen; or a pharmaceutically acceptable salt thereof.
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