发明授权
- 专利标题: Modified radioantibody fragments for reduced renal uptake
- 专利标题(中): 用于减少肾摄取的改良的放射性抗体片段
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申请号: US309319申请日: 1994-09-20
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公开(公告)号: US5670132A公开(公告)日: 1997-09-23
- 发明人: Gary L. Griffiths , Hans J. Hansen , Habibe Karacay
- 申请人: Gary L. Griffiths , Hans J. Hansen , Habibe Karacay
- 申请人地址: NJ Morris Plains
- 专利权人: Immunomedics, Inc.
- 当前专利权人: Immunomedics, Inc.
- 当前专利权人地址: NJ Morris Plains
- 主分类号: A61K51/00
- IPC分类号: A61K51/00 ; A61K51/10 ; C07K16/00 ; A61M36/14
摘要:
PEG-modified-Tc-99m-radiolabeled antibody fragments are useful for radioimmunodetection of tumors and infectious lesions and display striking reductions in renal uptake and retention of radioisotope compared to non-PEG-modified fragments.
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