发明授权
US5679857A Method of preparing D-amino acid-N-(S)-.alpha.-alkylbenzylamide
失效
D-氨基酸-N-(S)-α-烷基苄基酰胺的制备方法
- 专利标题: Method of preparing D-amino acid-N-(S)-.alpha.-alkylbenzylamide
- 专利标题(中): D-氨基酸-N-(S)-α-烷基苄基酰胺的制备方法
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申请号: US558663申请日: 1995-11-16
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公开(公告)号: US5679857A公开(公告)日: 1997-10-21
- 发明人: Toyoto Hijiya , Chiaki Mochizuki , Tadashi Takemoto
- 申请人: Toyoto Hijiya , Chiaki Mochizuki , Tadashi Takemoto
- 申请人地址: JPX Tokyo
- 专利权人: Ajinomoto Co., Inc.
- 当前专利权人: Ajinomoto Co., Inc.
- 当前专利权人地址: JPX Tokyo
- 优先权: JPX6-304783 19941208
- 主分类号: C07B53/00
- IPC分类号: C07B53/00 ; C07C231/12 ; C07C231/16 ; C07C237/06 ; C07C231/18
摘要:
L-amino acid amides are converted to the corresponding D-amino acid amides. An amide formed from an L-amino acid and an optically active (S)-.alpha.-alkylbenzylamine is subjected to dehydration condensation with an aryl aldehyde to form a Schiff's base, which is racemized at the amino acid moiety in the presence of a base to yield an N-allylidene-D-amino acid-(S)-amide. The less-soluble diastereomer N-allylidene-D-amino acid-(S)-amide is crystallized from the reaction mixture and recovered by means of solid/liquid separation. The N-allylidene form is readily hydrolyzed into the amino acid-(S)-amide and the starting aldehyde.
公开/授权文献
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