发明授权
US5686060A Stable microbubble suspensions comprising saturated phospholipids for
ultrasound echography
失效
稳定的微泡悬浮液，包括用于超声回波的饱和磷脂
- 专利标题： Stable microbubble suspensions comprising saturated phospholipids for ultrasound echography
- 专利标题（中）： 稳定的微泡悬浮液，包括用于超声回波的饱和磷脂
-
申请号： US420677申请日： 1995-04-12
-
公开(公告)号： US5686060A公开(公告)日： 1997-11-11
- 发明人: Michel Schneider , Jean Brochot , Jerome Puginier , Feng Yan
- 申请人： Michel Schneider , Jean Brochot , Jerome Puginier , Feng Yan
- 申请人地址： NLX
- 专利权人： Bracco International BV
- 当前专利权人： Bracco International BV
- 当前专利权人地址： NLX
- 优先权： EPX92810837 19921102
- 主分类号： A61K47/24
- IPC分类号： A61K47/24 ; A61B8/08 ; A61B8/12 ; A61B8/13 ; A61K9/127 ; A61K49/00 ; A61K49/22 ; B01F3/04 ; B01J13/02
摘要：
Disclosed are injectable suspensions of gas filled microbubbles in an aqueous carrier liquid usable as contrast agents in ultrasonic echography. The suspensions comprise amphipathic compounds of which at least one may be a laminarized phospholipid as a stabilizer of the microbubbles against collapse with time and pressure. The concentration of phospholipids in the carrier liquid is below 0.01% wt but is at least equal to or above that at which phospholipid molecules are present solely at the gas microbubble-liquid interface. Also disclosed is a method of preparation of the stable suspensions of air or gas filled microbubbles.
公开/授权文献
- US4430061A Orthodontic bracket assembly 公开/授权日：1984-02-07
信息查询
IPC分类:
