公开(公告)号：US06989141B2

公开(公告)日：2006-01-24

申请号：US10120390

申请日：2002-04-12

申请人： Michel Schneider ,  Feng Yan ,  Nadine Gercel, legal representative ,  Jerome Puginier ,  Maria-Bernadette Barrau ,  Philippe Bussat ,  Eva Hybl ,  Daniel Bichon

发明人： Pascal Grenier, deceased

IPC分类号： A61B8/00

CPC分类号： A61K49/223

摘要： Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophilic stabilizers. The laminarized surfactants can be in the form of liposomes. The suspensions are obtained by exposing the laminarized surfactants to air or a gas before or after admixing with an aqueous phase. One can impart outstanding resistance against collapse under pressure to these gas-filled microbubbles used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003.

公开(公告)号：US20050207980A1

公开(公告)日：2005-09-22

申请号：US11085169

申请日：2005-03-22

申请人： Michel Schneider ,  Feng Yan ,  Pascal Grenier ,  Nadine Garcel ,  Jerome Puginier ,  Marie-Bernadette Barrau ,  Philippe Bussat ,  Eva Hybl ,  Daniel Bichon

发明人： Michel Schneider ,  Feng Yan ,  Pascal Grenier ,  Nadine Garcel ,  Jerome Puginier ,  Marie-Bernadette Barrau ,  Philippe Bussat ,  Eva Hybl ,  Daniel Bichon

IPC分类号： A61B8/00 ,  A61B5/055 ,  A61K9/10 ,  A61K9/127 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/22 ,  A61K47/24 ,  A61K47/26 ,  A61K47/28 ,  A61K47/34 ,  A61K47/36 ,  A61K49/00 ,  A61K49/22

CPC分类号： A61K49/223 ,  A61K49/227 ,  Y10S514/975

摘要： Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophilic stabilizers. The laminarized surfactants can be in the form of liposomes. The suspensions are obtained by exposing the laminarized surfactants to air or a gas before or after admixing with an aqueous phase.

摘要翻译： 在超声波回波成像中用作成像造影剂的水相中的气体或空气填充的微泡悬浮液。 它们含有层状表面活性剂和任选的亲水稳定剂。 层状表面活性剂可以是脂质体的形式。 通过在与水相混合之前或之后将层状表面活性剂暴露于空气或气体中获得悬浮液。

公开(公告)号：US06485705B1

公开(公告)日：2002-11-26

申请号：US09630537

申请日：2000-08-01

申请人： Michel Schneider ,  Feng Yan ,  Pascal Grenier ,  Jerome Puginier ,  Marie-Bernadette Barrau ,  Philippe Bussat ,  Eva Hybl ,  Daniel Bichon

发明人： Michel Schneider ,  Feng Yan ,  Pascal Grenier ,  Jerome Puginier ,  Marie-Bernadette Barrau ,  Philippe Bussat ,  Eva Hybl ,  Daniel Bichon

IPC分类号： A61B800

CPC分类号： A61K49/223 ,  A61K49/227 ,  Y10S514/975

摘要： Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophilic stabilizers. The laminarized surfactants can be in the form of liposomes. The suspensions are obtained by exposing the laminarized surfactants to air or a gas before or after admixing with an aqueous phase.

摘要翻译： 在超声波回波成像中用作成像造影剂的水相中的气体或空气填充的微泡悬浮液。 它们含有层状表面活性剂和任选的亲水稳定剂。 层状表面活性剂可以是脂质体的形式。 通过在与水相混合之前或之后将层状表面活性剂暴露于空气或气体中获得悬浮液。

公开(公告)号：US06136293A

公开(公告)日：2000-10-24

申请号：US21150

申请日：1998-02-10

申请人： Michel Schneider ,  Feng Yan ,  Pascal Grenier, deceased ,  Jerome Puginier ,  Marie-Bernadette Barrau ,  Philippe Bussat ,  Eva Hybl ,  Daniel Bichon

发明人： Michel Schneider ,  Feng Yan ,  Pascal Grenier, deceased ,  Jerome Puginier ,  Marie-Bernadette Barrau ,  Philippe Bussat ,  Eva Hybl ,  Daniel Bichon

IPC分类号： A61B8/00 ,  A61B5/055 ,  A61K9/10 ,  A61K9/127 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/22 ,  A61K47/24 ,  A61K47/26 ,  A61K47/28 ,  A61K47/34 ,  A61K47/36 ,  A61K49/00 ,  A61K49/22

CPC分类号： A61K49/223 ,  A61K49/227 ,  Y10S514/975

摘要： Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophilic stabilizers. The laminarized surfactants can be in the form of liposomes. The suspensions are obtained by exposing the laminarized surfactants to air or a gas before or after admixing with an aqueous phase.

摘要翻译： 在超声波回波成像中用作成像造影剂的水相中的气体或空气填充的微泡悬浮液。 它们含有层状表面活性剂和任选的亲水稳定剂。 层状表面活性剂可以是脂质体的形式。 通过在与水相混合之前或之后将层状表面活性剂暴露于空气或气体中获得悬浮液。

公开(公告)号：US5908610A

公开(公告)日：1999-06-01

申请号：US883592

申请日：1997-06-26

申请人： Michel Schneider ,  Jean Brochot ,  Jerome Puginier ,  Feng Yan

发明人： Michel Schneider ,  Jean Brochot ,  Jerome Puginier ,  Feng Yan

IPC分类号： A61K47/24 ,  A61B8/08 ,  A61B8/12 ,  A61B8/13 ,  A61K9/127 ,  A61K49/00 ,  A61K49/22 ,  B01F3/04 ,  B01J13/02

CPC分类号： A61K49/225 ,  A61K49/223

摘要： Disclosed are injectable suspensions of gas filled microbubbles in an aqueous carrier liquid usable as contrast agents in ultrasonic echography. The suspensions comprise amphipathic compounds of which at least one may be a laminarized phospholipid as a stabiliser of the microbubbles against collapse with time and pressure. The concentration of phospholipids in the carrier liquid is below 0.01% wt but is at least equal to or above that at which phospholipid molecules are present solely at the gas microbubble-liquid interface. Also disclosed is a method of preparation of the stable suspensions of air or gas filled microbubbles.

摘要翻译： 公开了在超声波回波成像中可用作造影剂的水性载体液体中的气体填充微泡的可注射悬浮液。 悬浮液包含两亲性化合物，其中至少一种可以是层状磷脂作为微泡的稳定剂，以防止随时间和压力而塌陷。 载体液体中磷脂的浓度低于0.01％wt，但至少等于或高于磷脂分子仅存在于气体微泡液界面的浓度。 还公开了制备空气或气体填充的微泡的稳定悬浮液的方法。

公开(公告)号：US5380519A

公开(公告)日：1995-01-10

申请号：US128540

申请日：1993-09-29

申请人： Michel Schneider ,  Daniel Bichon ,  Philippe Bussat ,  Jerome Puginier ,  Eva Hybl-Sutherland

发明人： Michel Schneider ,  Daniel Bichon ,  Philippe Bussat ,  Jerome Puginier ,  Eva Hybl-Sutherland

IPC分类号： A61B8/00 ,  A61B5/055 ,  A61K9/10 ,  A61K9/127 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/22 ,  A61K47/24 ,  A61K47/26 ,  A61K47/28 ,  A61K47/34 ,  A61K47/36 ,  A61K49/00 ,  A61K49/22 ,  A61B8/08 ,  A61B8/14 ,  A61K37/22

CPC分类号： A61K49/223 ,  A61K49/227 ,  Y10S514/975

摘要： Gas or air filled microbubble suspensions in aqueous phase usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophilic stabilizers. The laminarized surfactants can be in the form of liposomes. The suspensions are obtained by exposing the laminarized surfactants to air or a gas before or after admixing with an aqueous phase.

摘要翻译： 气相或空气填充的微波混悬液在水相中可用作超声波回波成像中的成像造影剂。 它们含有层状表面活性剂和任选的亲水稳定剂。 层状表面活性剂可以是脂质体的形式。 通过在与水相混合之前或之后将层状表面活性剂暴露于空气或气体中获得悬浮液。

公开(公告)号：US20120093732A1

公开(公告)日：2012-04-19

申请号：US13224129

申请日：2011-09-01

申请人： Michel Schneider ,  Feng Yan ,  David Lazarus ,  Jean Brochot ,  Jerome Puginier

发明人： Michel Schneider ,  Feng Yan ,  David Lazarus ,  Jean Brochot ,  Jerome Puginier

IPC分类号： A61B8/00 ,  A61K49/22

CPC分类号： A61K49/223 ,  A61K49/227

摘要： The invention is directed to injectable suspensions of gas-filled microvesicles, as well as methods of preparing and using the same, especially as ultrasound contrast agents.

摘要翻译： 本发明涉及气体填充微泡的可注射悬浮液，以及制备和使用它们的方法，特别是作为超声造影剂。

公开(公告)号：US07083778B2

公开(公告)日：2006-08-01

申请号：US10385473

申请日：2003-03-12

申请人： Michel Schneider ,  Feng Yan ,  Nadine Garcel, legal representative ,  Jerome Puginier ,  Marie-Bernadette Barrau ,  Philippe Bussat ,  Eva Hybl ,  Daniel Bichon

发明人： Pascal Grenier, deceased

IPC分类号： A18B8/00

CPC分类号： A61K49/223

摘要： Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain surfactants and, optionally, hydrophilic stabilizers. The surfactants can be in the form of liposomes. The suspensions are obtained by exposing the surfactants to air or a gas before or after admixing with an aqueous phase. One can impart outstanding resistance against collapse under pressure to these gas-filled microbubbles used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003. Contrast agents with particular mixtures of gases are also disclosed that have advantageous properties.

公开(公告)号：USRE39146E1

公开(公告)日：2006-06-27

申请号：US09115963

申请日：1998-07-15

申请人： Michel Schneider ,  Feng Yan ,  Nadine Garcel ,  Jerome Puginier ,  Marie-Bernadette Barrau ,  Philippe Bussat ,  Eva Hybl ,  Daniel Bichon

发明人： Pascal Grenier

IPC分类号： A61K49/00 ,  A61B8/00

CPC分类号： A61K49/223 ,  A61B8/481

摘要： One can impart outstanding resistance against collapse under pressure to gas-filled microvesicle used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003.

公开(公告)号：US20060034771A1

公开(公告)日：2006-02-16

申请号：US11231865

申请日：2005-09-22

申请人： Michel Schneider ,  Feng Yan ,  Pascal Grenier ,  Nadine Garcel ,  Jerome Puginier ,  Maria Barrau ,  Philippe Bussat ,  Eva Hybl ,  Daniel Bichon

发明人： Michel Schneider ,  Feng Yan ,  Pascal Grenier ,  Nadine Garcel ,  Jerome Puginier ,  Maria Barrau ,  Philippe Bussat ,  Eva Hybl ,  Daniel Bichon

IPC分类号： A61K49/22

CPC分类号： A61K49/223

摘要： Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophilic stabilizers. The laminarized surfactants can be in the form of liposomes. The suspensions are obtained by exposing the laminarized surfactants to air or a gas before or after admixing with an aqueous phase. One can impart outstanding resistance against collapse under pressure to these gas-filled microbubbles used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003.