发明授权
- 专利标题: Aromatic amine compounds, Their method of preparation and pharmaceutical compositions in which they are present
- 专利标题(中): 芳族胺化合物,它们的制备方法和其中存在的药物组合物
-
申请号: US208672申请日: 1994-03-11
-
公开(公告)号: US5686609A公开(公告)日: 1997-11-11
- 发明人: Xavier Emonds-Alt , Pierre Goulaouic , Vincenzo Proietto , Didier Van Broeck
- 申请人: Xavier Emonds-Alt , Pierre Goulaouic , Vincenzo Proietto , Didier Van Broeck
- 申请人地址: FRX Paris
- 专利权人: Sanofi
- 当前专利权人: Sanofi
- 当前专利权人地址: FRX Paris
- 优先权: FRX8914517 19891106; FRX9007534 19900615
- 主分类号: C07D295/12
- IPC分类号: C07D295/12 ; A61K31/4427 ; A61K31/443 ; A61K31/4433 ; A61K31/445 ; A61K31/495 ; A61P9/00 ; A61P25/04 ; A61P29/00 ; A61P37/08 ; C07D211/14 ; C07D211/16 ; C07D211/18 ; C07D211/22 ; C07D211/28 ; C07D211/32 ; C07D211/70 ; C07D295/08 ; C07D295/13 ; C07D295/192 ; C07D317/58 ; C07D317/60 ; C07D401/06 ; C07D401/12 ; C07D405/12 ; C07D409/06 ; C07D409/12 ; C07D413/12 ; C07D417/12 ; C07D521/00 ; H01N43/60 ; C07D211/06 ; C07D405/00
摘要:
The invention relates to compounds of the formula ##STR1## in which: m is 2 or 3; Ar and Ar' independently are a thienyl group; a substituted or unsubstituted phenyl group; or an imidazolyl group; it also being possible for Ar' to be a benzothienyl group which is unsubstituted or substituted by a halogen; a naphthyl group which is unsubstituted or substituted by a halogen; a biphenyl group; or a substituted or unsubstituted indolyl; X is hydrogen; X' is hydrogen or a hydroxyl group or is joined to X" below to form a carbon-carbon bond, or X and X' together form an oxo group or a dialkylaminoalkoxyimino group of the formula .dbd.N--O--(CH.sub.2).sub.p --Am, in which p is 2 or 3 and Am is a dialkylamino group; Y is a nitrogen atom or a group C(X"), in which X" is hydrogen or forms a carbon-carbon bond with X'; Q is hydrogen, a C.sub.1 -C.sub.4 alkyl group or an aminoalkyl group of the formula --(CH.sub.2).sub.q --Am', in which q is 2 or 3 and Am' is a piperidino, 4-benzylpiperidino or dialkylamino group; R is hydrogen, a methyl group or a group (CH.sub.2).sub.n --L, in which n is an integer from 2 to 6 and L is hydrogen or an amino group; T is a group selected from ##STR2## W being an oxygen or sulfur atom; and Z is either hydrogen, or M or OM when T is the group --C(.dbd.O)--, or M when T is the group --C(.dbd.W)--NH--, M being hydrogen; a linear or branched alkyl; a substituted or unsubstituted phenylalkyl; a pyridylalkyl; a naphthylalkyl; a pyridylthioalkyl; a styryl; a 1-methylimidazol-2-ylthioalkyl; a 1-oxophenyl-3-indan-2-yl; or a substituted or unsubstituted aromatic or heteroaromatic group; or to one of their salts with mineral or organic acids. Application: neurokinin receptor antagonists.
公开/授权文献
- US6041571A Magnetic coupling for a capping apparatus 公开/授权日:2000-03-28
信息查询