发明授权
- 专利标题: Polysaccharide derivatives and drug carriers
- 专利标题(中): 多糖衍生物和药物载体
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申请号: US325296申请日: 1994-12-28
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公开(公告)号: US5688931A公开(公告)日: 1997-11-18
- 发明人: Hideo Nogusa , Hiroshi Hamana , Toshiro Yano , Masahiro Kajiki , Keiji Yamamoto , Satoshi Okuno , Shuichi Sugawara , Nobukazu Kashima , Kazuhiro Inoue
- 申请人: Hideo Nogusa , Hiroshi Hamana , Toshiro Yano , Masahiro Kajiki , Keiji Yamamoto , Satoshi Okuno , Shuichi Sugawara , Nobukazu Kashima , Kazuhiro Inoue
- 申请人地址: JPX Tokyo-to
- 专利权人: Drug Delivery System Institute, Ltd.
- 当前专利权人: Drug Delivery System Institute, Ltd.
- 当前专利权人地址: JPX Tokyo-to
- 优先权: JPX5-038635 19930226
- 主分类号: A61K47/48
- IPC分类号: A61K47/48 ; C08B37/00 ; C08B37/02 ; C07H13/02 ; C07K5/00 ; C08B37/08
摘要:
A novel polysaccharide derivative, a drug carrier comprising a novel polysaccharide derivative, and a drug complex are disclosed. The polysaccharide derivative according to the present invention comprises a polysaccharide having a carboxyl group in which a peptide chain is introduced at a part or all of the carboxyl groups of the polysaccharide. The peptide chain comprises 1-8 amino acids which may be the same or different. A part or all of the amino groups in the peptide chain which are not involved in the linkages with the carboxyl groups of the polysaccharide or the carboxyl groups in the peptide chain may form an acid amide linkage or an ester linkage with a carboxyl group, an amino group or a hydroxyl group of a third compound such as drugs. The polysaccharide derivative has a property of accumulating in a high amount at a tumor, and thus can deliver efficiently a drug which has a side-effect or a limited sustainment of the drug efficacy to the tumor.
公开/授权文献
- US4984381A Firearm wear analysis 公开/授权日:1991-01-15
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