发明授权
- 专利标题: Bicyclic fibrinogen antagonists
- 专利标题(中): 双相纤维蛋白原拮抗剂
-
申请号: US923794申请日: 1992-06-26
-
公开(公告)号: US5693636A公开(公告)日: 1997-12-02
- 发明人: William Edward Bondinell , James Francis Callahan , William Francis Huffman , Richard McCulloch Keenan , Thomas Wen-Fu Ku , Kenneth Allen Newlander
- 申请人: William Edward Bondinell , James Francis Callahan , William Francis Huffman , Richard McCulloch Keenan , Thomas Wen-Fu Ku , Kenneth Allen Newlander
- 申请人地址: PA Philadelphia
- 专利权人: SmithKline Beecham Corporation
- 当前专利权人: SmithKline Beecham Corporation
- 当前专利权人地址: PA Philadelphia
- 主分类号: A61K31/55
- IPC分类号: A61K31/55 ; A61K31/551 ; A61K31/5513 ; A61K31/675 ; A61K31/69 ; A61P7/02 ; A61P9/08 ; A61P9/10 ; C07D223/16 ; C07D243/12 ; C07D243/14 ; C07D267/14 ; C07D281/10 ; C07D471/04 ; C07D491/048 ; C07F9/40 ; C07D403/00
摘要:
This invention relates to compounds of the formula: ##STR1## wherein A.sup.1 to A.sup.5 form an accessible substituted seven-membered ring, which may be saturated or unsaturated, optionally containing up to two heteroatoms chosen from the group of O, S and N wherein S and N may be optionally oxidized; D.sup.1 to D.sup.4 form an accessible substituted six membered ring, optionally containing up to two nitrogen atoms; R is at least one substituent chosen from the group of R.sup.7, or Q--C.sub.1-4 alkyl, Q--C.sub.2-4 alkenyl, Q--C.sub.2-4 alkynyl, preferably substituted by an acidic function; R* is H, Q--C.sub.1-6 alkyl, Q--C.sub.1-6 oxoalkyl, Q--C.sub.2-6 alkenyl or Q--C.sub.2-4 alkynyl, C.sub.3-6 cycloalkyl, Ar or Het, optionally substituted by one or more substitutents; and R.sup.6 is preferably a substituent containing a basic nitrogen moiety; or a pharmaceutically acceptable salt thereof, which are effective for inhibiting platelet aggregation, pharmaceutical compositions for effecting such activity, and a method for inhibiting platelet aggregation.
公开/授权文献
- US4834906A Smectic A liquid crystal compositions 公开/授权日:1989-05-30
信息查询