发明授权
- 专利标题： Use of propylene oxide as an acid scavenger in peptide synthesis
- 专利标题（中）： 在肽合成中使用环氧丙烷作为酸清除剂
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申请号： US565465申请日： 1995-11-30
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公开(公告)号： US5698676A公开(公告)日： 1997-12-16
- 发明人: Madhup K. Dhaon
- 申请人： Madhup K. Dhaon
- 申请人地址： IL Abbott Park
- 专利权人： Abbott Laboratories
- 当前专利权人： Abbott Laboratories
- 当前专利权人地址： IL Abbott Park
- 主分类号： C07K1/04
- IPC分类号： C07K1/04 ; A61K38/00 ; C07K5/00 ; C07K7/00 ; C07K16/00
摘要：
A process of synthesizing a peptide using an alkylene oxide as an acid scavenger is provided. A process of the present invention can be used in a solid phase or solution phase synthetic process where peptide synthesis occurs by the sequential addition of N-.alpha.-amino-Boc-protected residues followed by acid deprotection of that N-.alpha.-amino protecting group and scavenging of the acid.
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