The present invention is directed to a fluorine-modified silicone derivative the organopolysiloxane chain which is partly substituted by the siloxane chain of the following general formula (1), (2) or (3), a preparation process thereof, intermediates useful for the preparation thereof and cosmetic compositions containing this derivative. ##STR1## wherein Rf and Rf' mean individually a perfluoroalkyl group having 1-20 carbon atoms or a .omega.-H-perfluoroalkyl group represented by the formula H(CF.sub.2).sub.t -- in which t stands for an integer of 1-20, R.sup.1 may be identical with or different from each other and means a straight-chain or branched aliphatic hydrocarbon group having 1-20 carbon atoms, or an alicyclic or aromatic hydrocarbon group having 5-10 carbon atoms, R.sup.2 denotes a hydrogen atom, a straight-chain or branched aliphatic hydrocarbon group having 1-20 carbon atoms, an alicyclic or aromatic hydrocarbon group having 5-10 carbon atoms, a perfluoroalkyl group having 1-20 carbon atoms, or a .omega.-H-perfluoroalkyl group represented by the formula H(CF.sub.2).sub.u --in which u stands for an integer of 1-20, R.sup.3 is a divalent hydrocarbon group having 2-16 carbon atoms, X and Y mean individually a single bond, --CO-- or a divalent hydrocarbon group having 1-6 carbon atoms, l stands for a number of 2-16, m and n are individually a number of 1-6, and r is a number of 0-50. Cosmetic compositions containing this compound have excellent water and oil repellency and are also good in lastingness of makeup and feeling upon use.