发明授权
- 专利标题： Phage-display of immunoglobulin heavy chain libraries
- 专利标题（中）： 噬菌体展示免疫球蛋白重链文库
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申请号： US437815申请日： 1995-05-09
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公开(公告)号： US5702892A公开(公告)日： 1997-12-30
- 发明人: Mary Jo Mulligan-Kehoe
- 申请人： Mary Jo Mulligan-Kehoe
- 申请人地址： DC Washington
- 专利权人： The United States of America as represented by the Department of Health and Human Services
- 当前专利权人： The United States of America as represented by the Department of Health and Human Services
- 当前专利权人地址： DC Washington
- 主分类号： C07K16/00
- IPC分类号： C07K16/00 ; C12N15/10 ; C40B40/02 ; G01N33/68 ; C12Q1/68 ; C12N15/13 ; C12N15/62 ; C12N15/70
摘要：
One aspect of the invention relates to a phage-display library that expresses single-chain recombinant binding proteins. Inserts in the library comprise immunoglobulin heavy chain framework regions flanking highly divergent, synthetically produced hypervariable regions. A second aspect of the invention relates to the use of single-chain recombinant binding proteins to inhibit the activity of an intracellular constituent. In the exemplary case presented, the activity of intracellular glucose-6-phosphate dehydrogenase was inhibited by intracellular expression of a cloned single-chain recombinant binding protein.
公开/授权文献
- US5029659A Torque detecting apparatus 公开/授权日：1991-07-09
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