发明授权
US5702894A Methods of analysis and manipulating of DNA utilizing mismatch repair
systems
失效
使用错配修复系统分析和操纵DNA的方法
- 专利标题： Methods of analysis and manipulating of DNA utilizing mismatch repair systems
- 专利标题（中）： 使用错配修复系统分析和操纵DNA的方法
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申请号： US460663申请日： 1995-06-02
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公开(公告)号： US5702894A公开(公告)日： 1997-12-30
- 发明人: Paul L. Modrich , Shin-San Su , Karin G. Au , Robert S. Lahue , Deani Lee Cooper , Leroy Worth, Jr.
- 申请人： Paul L. Modrich , Shin-San Su , Karin G. Au , Robert S. Lahue , Deani Lee Cooper , Leroy Worth, Jr.
- 申请人地址： NC Durham
- 专利权人： Duke University
- 当前专利权人： Duke University
- 当前专利权人地址： NC Durham
- 主分类号： C07K14/245
- IPC分类号： C07K14/245 ; C12N15/00 ; C12N15/10 ; C12Q1/68 ; C07H21/02 ; C07H21/04 ; C12P19/34
摘要：
A diagnostic method for detecting a base pair mismatch in a DNA duplex, comprising the steps of contacting at least one strand of a first DNA molecule with the complementary strand of a second DNA molecule under conditions such that base pairing occurs contacting a DNA duplex potentially containing a base pair mismatch with a mispair recognition protein under conditions suitable for the protein to form a specific complex only with the DNA duplex having a base pair mismatch, and not with a DNA duplex lacking a base pair mismatch, and detecting any complex as a measure of the presence of a base pair mismatch in the DNA duplex.
公开/授权文献
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