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发明授权
US5703096A Oxime derivatives, their preparation and their therapeutic use 失效
肟衍生物，其制备及其治疗用途

Oxime derivatives, their preparation and their therapeutic use
摘要：
Compounds of formula (I): ##STR1## wherein: R.sup.1 is hydrogen or alkyl; R.sup.2 is alkylene; R.sup.3 is hydrogen, alkyl, alkoxy, alkylthio, halogen, nitro group, amino group, monoalkylamino, dialkylamino, aryl, or aralkyl; X is aryl, or aromatic heterocyclic; Y is oxygen, sulfur or a group of formula >N-R.sup.4, in which R.sup.4 is hydrogen, alkyl or acyl; and Z is a group of formula (Za), (Zb), (Zc) or (Zd): ##STR2## and salts thereof can be used to treat or prevent are included those arising from hyperlipidemia, hyperglycemia, obesity, impaired glucose tolerance (IGT), insulin resistant non-IGT (NGT), non-diagnostic glucose tolerance, insulin resistance, diabetic complications, fatty liver, polycystic ovary syndrome (PCOS) and gestational diabetes mellitus (GDM); in addition the compounds of the present invention have aldose reductase inhibitory activity.
摘要（中）：

式（I）的化合物：其中：R 1是氢或烷基; R2是亚烷基; R 3是氢，烷基，烷氧基，烷硫基，卤素，硝基，氨基，一烷基氨基，二烷基氨基，芳基或芳烷基; X是芳基或芳族杂环; Y是氧，硫或式> N-R4的基团，其中R4是氢，烷基或酰基; 和Z是式（Za），（Zb），（Zc）或（Zd）的组：其可用于治疗或预防的组包括由高脂血症，高血糖症，肥胖症， 糖耐量异常（IGT），胰岛素抵抗非IGT（NGT），非诊断葡萄糖耐量，胰岛素抵抗，糖尿病并发症，脂肪肝，多囊卵巢综合征（PCOS）和妊娠糖尿病（GDM）; 此外，本发明的化合物还具有醛糖还原酶抑制活性。

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