发明授权
- 专利标题： Watersoluble azole antifungals
- 专利标题（中）： 水溶性唑类抗真菌剂
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申请号： US666270申请日： 1996-06-20
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公开(公告)号： US5707977A公开(公告)日： 1998-01-13
- 发明人: Jan Heeres , Leo Jacobus Jozef Backx , Luc Alfons Leo Van der Eycken , Frank Christopher Odds , Jean Louis Mesens
- 申请人： Jan Heeres , Leo Jacobus Jozef Backx , Luc Alfons Leo Van der Eycken , Frank Christopher Odds , Jean Louis Mesens
- 申请人地址： BEX Beerse
- 专利权人： Janssen Pharmaceutica, N.V.
- 当前专利权人： Janssen Pharmaceutica, N.V.
- 当前专利权人地址： BEX Beerse
- 主分类号： C07D405/14
- IPC分类号： C07D405/14 ; A01N43/653 ; A01N57/16 ; A61K31/34 ; A61K31/36 ; A61K31/41 ; A61K31/415 ; A61K31/495 ; A61K31/535 ; A61K31/675 ; A61P31/04 ; A61P31/10 ; C07D403/12 ; C07D407/14 ; C07D413/14 ; C07D521/00 ; C07F9/6558
摘要：
A compound of formula (I), ##STR1## an acid or base addition salt thereof or a stereochemically isomeric form thereof, wherein A and B taken together form --N.dbd.CH--, --CH.dbd.N--, --CH.sub.2 --CH.sub.2, CH.dbd.CH--, --C(.dbd.O)--CH.sub.2 --, --CH.sub.2 --C(.dbd.O); D is a radical of formula ##STR2## L is a radical of formula ##STR3## Alk is a C.sub.1-4 alkanediyl radical; R.sup.1 is halo; R.sup.2 is hydrogen or halo; R.sup.3 is hydrogen, C.sub.1-6 alkyl, phenyl or halophenyl; R.sup.4 is hydrogen, C.sub.1-6 alkyl, phenyl or halophenyl; R.sup.5 is hydrogen or C.sub.1-6 alkyl; R.sup.6 is hydrogen, C.sub.1-6 alkyl, C.sub.1-6 alkyloxycarbonyl, or R.sup.5 and R.sup.6 taken together with the nitrogen atom to which they are attached form a heterocyclic ring. Active intermediates, compositions and methods of preparing compounds, compositions are described.
公开/授权文献
- USRE32159E Beater 公开/授权日：1986-05-27
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