发明授权
- 专利标题： Method of screening compounds which inhibit P. gingivalis lipopolysaccharide from inhibiting the extravasation of leukocytes
- 专利标题（中）： 筛选抑制牙龈卟啉菌脂多糖抑制白细胞外渗的化合物的方法
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申请号： US453191申请日： 1995-05-30
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公开(公告)号： US5712102A公开(公告)日： 1998-01-27
- 发明人: Richard P. Darveau
- 申请人： Richard P. Darveau
- 申请人地址： NY New York
- 专利权人： Bristol-Myers Squibb Company
- 当前专利权人： Bristol-Myers Squibb Company
- 当前专利权人地址： NY New York
- 主分类号： A61K8/00
- IPC分类号： A61K8/00 ; A61K8/66 ; A61K8/99 ; A61K35/74 ; A61K38/46 ; A61K39/395 ; A61P31/04 ; A61Q11/00 ; C07K16/12 ; C12Q1/18 ; G01N33/50 ; G01N33/554 ; G01N33/569
摘要：
The lipopolysaccharide of bacteria associated with chronic inflammatory diseases is unable to induce expression of leukocyte adhesion molecules, or selectins, on endothelial cells, and is also capable of inhibiting the induction of selectin expression by bacteria normally associated with acute endotoxin disease. New approaches to treatment of these diseases, and the diagnosis of susceptibility to chronic bacterial-associated inflammatory diseases, are provided.
公开/授权文献
- US4965114A Optical recording medium 公开/授权日：1990-10-23
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