发明授权
US5723606A Condensed benzazepine derivative and pharmaceutical composition thereof
失效
浓缩的苯并氮杂衍生物及其药物组合物
- 专利标题: Condensed benzazepine derivative and pharmaceutical composition thereof
- 专利标题(中): 浓缩的苯并氮杂衍生物及其药物组合物
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申请号: US586686申请日: 1996-01-19
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公开(公告)号: US5723606A公开(公告)日: 1998-03-03
- 发明人: Akihiro Tanaka , Hiroyuki Koshio , Nobuaki Taniguchi , Akira Matsuhisa , Ken-ichiro Sakamoto , Atsuki Yamazaki , Takeyuki Yatsu
- 申请人: Akihiro Tanaka , Hiroyuki Koshio , Nobuaki Taniguchi , Akira Matsuhisa , Ken-ichiro Sakamoto , Atsuki Yamazaki , Takeyuki Yatsu
- 申请人地址: JPX Tokyo
- 专利权人: Yamanouchi Pharmaceutical Co., Ltd.
- 当前专利权人: Yamanouchi Pharmaceutical Co., Ltd.
- 当前专利权人地址: JPX Tokyo
- 优先权: JPX5-180435 19930721
- 主分类号: A61K31/40
- IPC分类号: A61K31/40 ; A61K31/415 ; A61K31/425 ; A61K31/44 ; A61K31/55 ; A61P1/16 ; A61P3/10 ; A61P7/02 ; A61P9/08 ; C07C233/64 ; C07D209/48 ; C07D223/16 ; C07D487/04 ; C07D498/04 ; C07D513/04 ; C07D223/20
摘要:
This invention relates to nitrogen-containing aromatic 5-membered ring-condensed benzazepine derivatives represented by the general formula (I) ##STR1## (symbols in the formula have the following meanings; ring B: a nitrogen-containing aromatic 5-membered ring having at least 1 nitrogen atom and optionally one oxygen or sulfur atom, which may optionally have substituent(s), R.sup.1 and R.sup.2 : these may be the same or different from each other and each represents a hydrogen atom, a halogen atom, a lower alkyl group, an amino group which may optionally be substituted by lower alkyl group(s), or a lower alkoxy group, A: a single bond; a group represented by the formula --NHCO--(CR.sup.3 R.sup.4).sub.n --, n: 0 or an integer of from 1 to 3, R.sup.3 and R.sup.4 : these may be the same or different from each other and each represents a hydrogen atom, a lower alkyl group (provided that R.sup.3 and R.sup.4 may together form a lower alkylene group having 2 to 7 carbon atoms), and ring C: a benzene ring which may optionally have substituent(s)) and salts thereof; to pharmaceutical compositions which contain these compounds as an active ingredient and to intermediates which are useful in synthesizing these compounds. The compounds of this invention are useful as arginine vasopressin antagonists.