A method of manufacturing a cold-rolled can steel sheet having less planar anisotropy and achieving good workability. Rough-rolling is first performed on a continuously-cast slab. The slab has a composition essentially consisting of: C: 0.004 wt % or lower; Mn: 0.05-0.5 wt %; P: 0.02 wt % or lower; Al: 0.005-0.07 wt %; N: 0.004 wt % or lower; and Nb: 0.001-0.018 wt %, the rest being Fe and unavoidable impurities. A resultant sheet bar is then subjected to hot rolling which is completed at a finishing rolling temperature at an Ar.sub.3 transformation point or higher. The resultant sheet bar is coiled at a temperature range from 450.degree.-700.degree. C. Subsequently, the resultant sheet bar undergoes primary cold rolling before continuous annealing, which is performed at a recrystallization temperature or higher, and secondary cold rolling. The primary and secondary cold rolling are respectively performed at reduction ratios satisfying the following conditions of: 88%.gtoreq.CR.sub.1 %+0.36.times.CR.sub.2 .ltoreq.105% wherein CR.sub.1 : reduction ratio of the primary cold rolling CR.sub.2 : reduction ratio of the secondary cold rolling